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Characterization of long living yeast deletion mutants that lack mitochondrial metabolism genes DSS1, PPA2 and AFG3
(Elsevier, 2019-07)
Molecular mechanisms of aging and longevity are still mostly unknown. Mitochondria play central roles in cellular metabolism and aging. In this study, we identified three deletion mutants of mitochondrial metabolism genes ...
Genomewide elucidation of drug resistance mechanisms for systemically used antifungal drugs amphotericin B, caspofungin, and voriconazole in the budding yeast
(American Society for Microbiology, 2019)
There are only a few antifungal drugs used systemically in treatment, and invasive fungal infections that are resistant to these drugs are an emerging problem in health care. In this study, we performed a high-copy-number ...
tRNA wobble base modifications and boric acid resistance in yeast: Boron-resistant deletion mutants induce the general amino acid control mechanism and activate boron efflux
(Springer, 2020-05)
Boric acid is essential for plants and has many vital roles in animals and microorganisms. However, its high doses are toxic to all organisms. We previously screened yeast deletion collections to identify boric acid-resistant ...
Identification of respiratory chain gene mutations that shorten replicative life span in yeast
(Elsevier, 2012-02)
Aging is the progressive accumulation of alterations in cells that elevates the risk of death. The mitochondrial theory of aging postulates that free radicals produced by the mitochondrial respiratory system contribute to ...
Compartmentalization and regulation of mitochondrial function by methionine sulfoxide reductases in yeast
(American Chemical Society, 2010-10)
Elevated levels of reactive oxygen species can damage proteins. Sulfur-containing amino acid residues, cysteine and methionine, are particularly susceptible to such damage. Various enzymes evolved to protect proteins or ...
Characterization of a cDNA from Beta maritima that confers nickel tolerance in yeast
(Elsevier, 2014-04)
Nickel is an essential micronutrient due to its involvement in many enzymatic reactions as a cofactor. However, excess of this element is toxic to biological systems. Here, we constructed a cDNA library from Beta maritima ...
Thiol peroxidase deficiency leads to increased mutational load and decreased fitness in saccharomyces cerevisiae
(Genetics Society of America, 2014-11)
Thiol peroxidases are critical enzymes in the redox control of cellular processes that function by reducing low levels of hydroperoxides and regulating redox signaling. These proteins were also shown to regulate genome ...
Functional characterization of new mutations in Wilson disease gene (ATP7B) using the yeast model
(Elsevier, 2015-07)
The Wilson disease gene, a copper transporting ATPase (Atp7b), is responsible for the sequestration of Cu into secretory vesicles, and this function is exhibited by the orthologous Ccc2p in the yeast. In this study, we ...
High-copy overexpression screening reveals PDR5 as the main doxorubicin resistance gene in yeast
(Public Library of Science, 2015-12)
Doxorubicin is one of the most potent anticancer drugs used in the treatment of various cancer types. The efficacy of doxorubicin is influenced by the drug resistance mechanisms and its cytotoxicity. In this study, we ...
The roles of thiol oxidoreductases in yeast replicative aging
(Elsevier, 2010-11)
Thiol-based redox reactions are involved in the regulation of a variety of biological functions, such as protection against oxidative stress, signal transduction and protein folding. Some proteins involved in redox regulation ...
