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Effects of deleting mitochondrial antioxidant genes on life span
(Wiley, 2007-04)
Reactive oxygen species (ROS) damage biomolecules, accelerate aging, and shorten life span, whereas antioxidant enzymes mitigate these effects. Because mitochondria are a primary site of ROS generation and also a primary ...
Methionine sulfoxide reduction and the aging process
(Wiley, 2007-04)
Aging has been described for multicellular and asymmetrically dividing organisms, but the mechanisms are poorly understood. Oxidation of proteins is considered to be one of the major factors that leads to aging. Oxidative ...
Genome-wide identification of genes that play a role in boron stress response in yeast
(Elsevier BV., 2011-02)
Boron is an essential micronutrient for plants and it is either necessary or beneficial for animals. Studies identified only few genes related to boron metabolism thus far and details of how boron is imported into cells ...
Assessment of chronological lifespan dependent molecular damages in yeast lacking mitochondrial antioxidant genes
(Elsevier, 2010-09)
The free radical theory of aging states that oxidative damage to biomolecules causes aging and that antioxidants neutralize free radicals and thus decelerate aging. Mitochondria produce most of the reactive oxygen species, ...
Effect of thioredoxin deletion and p53 cysteine replacement on human p53 activity in wild-type and thioredoxin reductase null yeast
(American Chemical Society, 2009)
Reporter gene transactivation by human p53 is inhibited in budding yeast lacking the TRR1 gene encoding thioredoxin reductase. To investigate the role of thioredoxin in controlling p53 activity, the level of reporter gene ...
Characterization of two genes encoding metal tolerance proteins from Beta vulgaris subspecies maritima that confers manganese tolerance in yeast
(Springer, 2013)
Manganese (Mn2+) is an essential micronutrient in plants. However increased Mn2+ levels are toxic to plant cells. Metal tolerance proteins (MTPs), member of cation diffusion facilitator protein (CDF) family, have important ...
Compartmentalization and regulation of mitochondrial function by methionine sulfoxide reductases in yeast
(American Chemical Society, 2010-10)
Elevated levels of reactive oxygen species can damage proteins. Sulfur-containing amino acid residues, cysteine and methionine, are particularly susceptible to such damage. Various enzymes evolved to protect proteins or ...
MsrB1 (methionine-R-sulfoxide reductase 1) knock-out mice: Roles of MsrB1 in redox regulation and identification of a novel selenoprotein form
(American Society for Biochemistry and Molecular Biology, 2009-02)
Protein oxidation has been linked to accelerated aging and is a contributing factor to many diseases. Methionine residues are particularly susceptible to oxidation, but the resulting mixture of methionine R-sulfoxide ...
Functional analysis of free methionine-R-sulfoxide reductase from saccharomyces cerevisiae
(American Society for Biochemistry and Molecular Biology, 2009-02)
Methionine sulfoxide reductases (Msrs) are oxidoreductases that catalyze thiol-dependent reduction of oxidized methionines. MsrA and MsrB are the best known Msrs that repair methionine S-sulfoxide (Met-S-SO) and ...
Identification of respiratory chain gene mutations that shorten replicative life span in yeast
(Elsevier, 2012-02)
Aging is the progressive accumulation of alterations in cells that elevates the risk of death. The mitochondrial theory of aging postulates that free radicals produced by the mitochondrial respiratory system contribute to ...
