Now showing items 1-6 of 6
Therapeutic applications of bioactive sphingolipids in hematological malignancies
Sphingolipids are sphingosine-based lipid molecules that have important functions in cellular signal transduction and in a variety of cellular processes including proliferation, differentiation, programmed cell death ...
Multidrug resistance in chronic myeloid leukemia
Chronic myeloid leukemia (CML) is characterized by the accumulation of Philadelphia chromosome-positive (Ph+) myeloid cells. Ph+ cells occur via a reciprocal translocation between the long arms of chromosomes 9 and 22 ...
Novel agents targeting bioactive sphingolipids for the treatment of cancer
(Bentham Science Publishers, 2013-01)
Sphingolipids are a class of lipids that have important functions in a variety of cellular processes such as, differentiation, proliferation, senescence, apoptosis and chemotherapeutic resistance. The most widely studied ...
An update on molecular biology and drug resistance mechanisms of multiple myeloma
Multiple myeloma (MM), a neoplasm of plasma cells, is the second most common hematological malignancy. Incidance rates increase after age 40. MM is most commonly seen in men and African-American population. There are several ...
Therapeutic potential of targeting ceramide/glucosylceramide pathway in cancer
Sphingolipids including ceramides and its derivatives such as ceramide-1-phosphate, glucosylceramide (GlcCer), and sphingosine-1-phosphate are essential structural components of cell membranes. They now recognized as novel ...
The role of cysteine cathepsins in cancer progression and drug resistance
Cysteine cathepsins are lysosomal enzymes belonging to the papain family. Their expression is misregulated in a wide variety of tumors, and ample data prove their involvement in cancer progression, angiogenesis, metastasis, ...