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miR-17 in imatinib resistance and response to tyrosine kinase inhibitors in chronic myeloid leukemia cells

Fıratlıgil, Burcu; Biray Avcı, Çığır; Baran, Yusuf (Zerbinis Medical Publications, 2013-04)

In this study we examined the expression levels of miR-17 which possesses oncogenic activities through downregulation of CDKN1A, p21 and E2F1 tumor suppressor genes, in imatinib sensitive and resistant chronic myeloid ...

Nilotinib significantly induces apoptosis in imatinib resistant K562 cells with wild-type BCR-ABL, as effectively as in parental sensitive counterparts

Ekiz, Hüseyin Atakan; Can, Geylani; Gündüz, Ufuk; Baran, Yusuf (Taylor & Francis, 2010-02)

Chronic myeloid leukemia (CML) is a hematological malignancy characterized by high levels of immature white blood cells. CML is caused by the translocation between chromosomes 9 and 22 (which results in the formation of ...