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Nilotinib significantly induces apoptosis in imatinib resistant K562 cells with wild-type BCR-ABL, as effectively as in parental sensitive counterparts

Ekiz, Hüseyin Atakan; Can, Geylani; Gündüz, Ufuk; Baran, Yusuf (Taylor & Francis, 2010-02)

Chronic myeloid leukemia (CML) is a hematological malignancy characterized by high levels of immature white blood cells. CML is caused by the translocation between chromosomes 9 and 22 (which results in the formation of ...

Apoptotic effects of resveratrol, a grape polyphenol, on imatinib-sensitive and resistant K562 chronic myeloid leukemia cells

Can, Geylani; Çakır, Zeynep; Kartal, Melis; Gündüz, Ufuk; Baran, Yusuf (International Institute of Anticancer Research, 2012-07)

To examine the antiproliferative and apoptotic effects of resveratrol on imatinib-sensitive and imatinib-resistant K562 chronic myeloid leukemia cells. Antiproliferative effects of resveratrol were determined by the ...