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One step forward, two steps back; Xeno-MicroRNAs reported in breast milk are artifacts
(Public Library of Science, 2016-01)
Background: MicroRNAs (miRNAs) are short RNA sequences that guide post-transcriptional regulation of gene expression via complementarity to their target mRNAs. Discovered only recently, miRNAs have drawn a lot of attention. ...
Categorization of species based on their microRNAs employing sequence motifs, information-theoretic sequence feature extraction, and k-mers
(Springer, 2017-12)
Background: Diseases like cancer can manifest themselves through changes in protein abundance, and microRNAs (miRNAs) play a key role in the modulation of protein quantity. MicroRNAs are used throughout all kingdoms and ...
The expressed MicroRNA-mRNA interactions of Toxoplasma gondii
(Frontiers Media S.A., 2018-01)
MicroRNAs (miRNAs) are involved in post-transcriptional modulation of gene expression and thereby have a large influence on the resulting phenotype. We have previously shown that miRNAs may be involved in the communication ...
On the performance of pre-microRNA detection algorithms
(Nature Publishing Group, 2017-12)
MicroRNAs are crucial for post-transcriptional gene regulation, and their dysregulation has been associated with diseases like cancer and, therefore, their analysis has become popular. The experimental discovery of miRNAs ...
Delineating the impact of machine learning elements in pre-microRNA detection
(PeerJ Inc., 2017)
Gene regulation modulates RNA expression via transcription factors. Posttranscriptional gene regulation in turn influences the amount of protein product through, for example, microRNAs (miRNAs). Experimental establishment ...
Intersection of MicroRNA and gene regulatory networks and their implication in cancer
(Bentham Science Publishers, 2014-09)
MicroRNAs (miRNAs) have attracted heightened attention for their role as post-transcriptional regulators of gene expression. It has become clear that miRNAs can both up- and downregulate protein expression. According to ...
MicroRNA categorization using sequence motifs and k-mers
(BioMed Central, 2017-03)
Background: Post-transcriptional gene dysregulation can be a hallmark of diseases like cancer and microRNAs (miRNAs) play a key role in the modulation of translation efficiency. Known pre-miRNAs are listed in miRBase, and ...
miR-17 in imatinib resistance and response to tyrosine kinase inhibitors in chronic myeloid leukemia cells
(Zerbinis Medical Publications, 2013-04)
In this study we examined the expression levels of miR-17 which possesses oncogenic activities through downregulation of CDKN1A, p21 and E2F1 tumor suppressor genes, in imatinib sensitive and resistant chronic myeloid ...
Computational methods for microRNA target prediction
(Springer, 2014)
MicroRNAs (miRNAs) are important players in gene regulation. The final and maybe the most important step in their regulatory pathway is the targeting. Targeting is the binding of the miRNA to the mature RNA via the RNA-induced ...
Computational and bioinformatics methods for microRNA gene prediction
(Springer, 2014)
MicroRNAs (miRNAs) have attracted ever-increasing interest in recent years. Since experimental approaches for determining miRNAs are nontrivial in their application, computational methods for the prediction of miRNAs have ...
