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Effect of molecular architecture on cell interactions and stealth properties of PEG
(American Chemical Society, 2017-09)
PEGylation, covalent attachment of PEG to therapeutic biomolecules, in which suboptimal pharmacokinetic profiles limiting their therapeutic utility are of concern, is a widely applied technology. However, this technology ...
Biodiversity, drug discovery, and the future of global health: Introducing the biodiversity to biomedicine consortium, a call to action
(University of Edinburgh, 2017-11)
Looking to nature for medicine is nothing new – we have been doing it for tens of thousands of
years and although modern pharmaceutical science has come a long way from those ancient roots,
nature is and will always be ...
An answer to colon cancer treatment by mesenchymal stem cell originated from adipose tissue
(Mashhad University of Medical Sciences, 2018-05)
Objective(s): Colon cancer is risen up with its complex mechanism that directly impacts on its treatment as well as its common prevalence. Mesenchymal stem cells (MSCs) have been considered as a therapeutic candidate for ...
The roles of epigenetic modifications of proapoptotic BID and BIM genes in imatinibresistant chronic myeloid leukemia cells
(Taylor & Francis, 2013-07)
In chronic myeloid leukemia (CML), epigenetic modifications such as promoter hypermethylation and inactive histone modification are known mechanisms of drug resistance. In our study, we investigated the roles of promoter ...
A novel mechanism of dasatinib-induced apoptosis in chronic myeloid leukemia; Ceramide synthase and ceramide clearance genes
(Springer, 2011-11)
Sphingolipids are bioeffector molecules that control various aspects of cell growth, proliferation, apoptosis, and drug resistance. Ceramides, the central molecule of sphingolipid metabolism, are inducer of apoptosis and ...
Imatinib-induced apoptosis: A possible link to topoisomerase enzyme inhibition
(Wiley-Blackwell, 2011-12-06)
Summary What is known and Objective: Imatinib is a specific BCR/ABL inhibitor, commonly used for the treatment of chronic myeloid leukaemia (CML), a hematological malignancy resulting from a chromosomal translocation that ...
Proteasome inhibitor bortezomib increases radiation sensitivity in androgen independent human prostate cancer cells
(Elsevier, 2010-04)
Objectives: To investigate the effects of a strong proteasome inhibitor, bortezomib alone or in combination with radiotherapy on androgen-independent DU145 human prostate cancer cells. Proteasomes play important roles in ...
The roles of antiapoptotic sphingosine kinase-1 and glucosylceramide genes in drug induced cell death of MCF-7 breast cancer cells
(Zerbinis Medical Publications, 2011-10)
Purpose: Sphingolipids are important signaling molecules mediating cell survival, proliferation, cell cycle regulation and apoptosis. Ceramide is the most vital sphingolipid which induces growth arrest, senescence, and ...
Bioactive sphingolipids in docetaxel-induced apoptosis in human prostate cancer cells
(Elsevier, 2012-03)
In this study, we examined the possible roles of ceramide/sphingosine-1-phosphate and ceramide/glucosyleceramide signaling in docetaxel-induced apoptosis by examining expression levels of the glucosyleceramide synthase and ...
Imatinib induces autophagy through BECLIN-1 and ATG5 genes in chronic myeloid leukemia cells
(Taylor & Francis, 2011-03)
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Hematology
Volume 16, Issue 2, March 2011, Pages 95-99
Imatinib induces autophagy ...
