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IRF6 is involved in the regulation of cell proliferation and transformation in MCF10A cells downstream of notch signaling

Zengin, Talip; Ekinci, Burcu; Küçükköse, Cansu; Yalçın Özuysal, Özden (Public Library of Science, 2015-07-10)

IRF6, a member of Interferon Regulatory Factors (IRF) family, is involved in orofacial and epidermal development. In breast cancer cell lines ectopic expression of IRF6 reduces cell numbers suggesting a role as negative ...

Proteasome inhibitor bortezomib increases radiation sensitivity in androgen independent human prostate cancer cells

Göktaş, Serdar; Baran, Yusuf; Ural, Ali Uğur; Yazıcı, Sertaç; Aydur, Emin; Başal, Şeref; Avcu, Ferit; Pekel, Aysel; Dirican, Bahar; Beyzadeoğlu, Murat (Elsevier, 2010-04)

Objectives: To investigate the effects of a strong proteasome inhibitor, bortezomib alone or in combination with radiotherapy on androgen-independent DU145 human prostate cancer cells. Proteasomes play important roles in ...