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Characterization of long living yeast deletion mutants that lack mitochondrial metabolism genes DSS1, PPA2 and AFG3

Muid, Khandaker Ashfaqul; Kimyon, Önder; Reza, Shahadat Hasan; Karakaya, Hüseyin Çağlar; Koç, Ahmet (Elsevier, 2019-07)

Molecular mechanisms of aging and longevity are still mostly unknown. Mitochondria play central roles in cellular metabolism and aging. In this study, we identified three deletion mutants of mitochondrial metabolism genes ...

tRNA wobble base modifications and boric acid resistance in yeast: Boron-resistant deletion mutants induce the general amino acid control mechanism and activate boron efflux

Uluışık, İrem; Karakaya, Hüseyin Çağlar; Koç, Ahmet (Springer, 2020-05)

Boric acid is essential for plants and has many vital roles in animals and microorganisms. However, its high doses are toxic to all organisms. We previously screened yeast deletion collections to identify boric acid-resistant ...