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Identification of respiratory chain gene mutations that shorten replicative life span in yeast
Aging is the progressive accumulation of alterations in cells that elevates the risk of death. The mitochondrial theory of aging postulates that free radicals produced by the mitochondrial respiratory system contribute to ...
High-copy overexpression screening reveals PDR5 as the main doxorubicin resistance gene in yeast
(Public Library of Science, 2015-12)
Doxorubicin is one of the most potent anticancer drugs used in the treatment of various cancer types. The efficacy of doxorubicin is influenced by the drug resistance mechanisms and its cytotoxicity. In this study, we ...
Assessment of chronological lifespan dependent molecular damages in yeast lacking mitochondrial antioxidant genes
The free radical theory of aging states that oxidative damage to biomolecules causes aging and that antioxidants neutralize free radicals and thus decelerate aging. Mitochondria produce most of the reactive oxygen species, ...