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Nilotinib significantly induces apoptosis in imatinib resistant K562 cells with wild-type BCR-ABL, as effectively as in parental sensitive counterparts

Ekiz, Hüseyin Atakan; Can, Geylani; Gündüz, Ufuk; Baran, Yusuf (Taylor & Francis, 2010-02)

Chronic myeloid leukemia (CML) is a hematological malignancy characterized by high levels of immature white blood cells. CML is caused by the translocation between chromosomes 9 and 22 (which results in the formation of ...

miR-17 in imatinib resistance and response to tyrosine kinase inhibitors in chronic myeloid leukemia cells

Fıratlıgil, Burcu; Biray Avcı, Çığır; Baran, Yusuf (Zerbinis Medical Publications, 2013-04)

In this study we examined the expression levels of miR-17 which possesses oncogenic activities through downregulation of CDKN1A, p21 and E2F1 tumor suppressor genes, in imatinib sensitive and resistant chronic myeloid ...