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Intersection of MicroRNA and gene regulatory networks and their implication in cancer
(Bentham Science Publishers, 2014-09)
MicroRNAs (miRNAs) have attracted heightened attention for their role as post-transcriptional regulators of gene expression. It has become clear that miRNAs can both up- and downregulate protein expression. According to ...
Computational methods for microRNA target prediction
(Springer, 2014)
MicroRNAs (miRNAs) are important players in gene regulation. The final and maybe the most important step in their regulatory pathway is the targeting. Targeting is the binding of the miRNA to the mature RNA via the RNA-induced ...
Computational and bioinformatics methods for microRNA gene prediction
(Springer, 2014)
MicroRNAs (miRNAs) have attracted ever-increasing interest in recent years. Since experimental approaches for determining miRNAs are nontrivial in their application, computational methods for the prediction of miRNAs have ...
Development of genomic simple sequence repeat markers in opium poppy by next-generation sequencing
(Springer, 2014-08)
Opium poppy (Papaver somniferum L.) is an important pharmaceutical crop with very few genetic marker resources. To expand these resources, we sequenced genomic DNA using pyrosequencing technology and examined the DNA ...
EPO mediates neurotrophic, neuroprotective, anti-oxidant, and anti-apoptotic effects via downregulation of miR-451 and miR-885-5p in SH-SY5Y neuron-like cells
(Frontiers Media, 2014-09)
Erythropoietin (EPO) is a neuroprotective cytokine, which has been applied in several animal models presenting neurological disorders. One of the proposed modes of action resulting in neuroprotection is post-transcriptional ...
Machine learning methods for microRNA gene prediction
(Humana Press, 2014)
MicroRNAs (miRNAs) are single-stranded, small, noncoding RNAs of about 22 nucleotides in length, which control gene expression at the posttranscriptional level through translational inhibition, degradation, adenylation, ...
Computational prediction of MicroRNAs from toxoplasma gondii potentially regulating the hosts' gene expression
(Elsevier, 2014-10)
MicroRNAs (miRNAs) were discovered two decades ago, yet there is still a great need for further studies elucidating their genesis and targeting in different phyla. Since experimental discovery and validation of miRNAs is ...
