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Computational methods for ab initio detection of microRNAs
(Frontiers Media, 2012)
MicroRNAs are small RNA sequences of 18-24 nucleotides in length, which serve as templates to drive post-transcriptional gene silencing. The canonical microRNA pathway starts with transcription from DNA and is followed by ...
Removing contamination from genomic sequences based on vector reference libraries
DNA is often sequenced after being cloned into a vector since this provides the possibility for using standard primers and removes the need to develop custom primers. In this way a certain amount of vector is sequenced ...
De novo markup language, a standard to represent de novo sequencing results from MS/MS data
Proteomics is the study of the proteins that can be derived from a genome. For the identification and sequencing of proteins, mass spectrometry has become the tool of choice. Within mass spectrometry-based proteomics, ...
Existing bioinformatics tools for the quantitation of post-translational modifications
Mass spectrometry (MS)-based proteomics, by itself, is a vast and complex area encompassing various mass spectrometers, different spectra, and search result representations. When the aim is quantitation performed in different ...