Now showing items 1-2 of 2
Thiol peroxidase deficiency leads to increased mutational load and decreased fitness in saccharomyces cerevisiae
(Genetics Society of America, 2014-11)
Thiol peroxidases are critical enzymes in the redox control of cellular processes that function by reducing low levels of hydroperoxides and regulating redox signaling. These proteins were also shown to regulate genome ...
High-copy overexpression screening reveals PDR5 as the main doxorubicin resistance gene in yeast
(Public Library of Science, 2015-12)
Doxorubicin is one of the most potent anticancer drugs used in the treatment of various cancer types. The efficacy of doxorubicin is influenced by the drug resistance mechanisms and its cytotoxicity. In this study, we ...