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dc.contributor.authorAydogan, Fadime
dc.contributor.authorBaykan, Sura
dc.contributor.authorSoliman, Gamal A.
dc.contributor.authorYusufoglu, Hasan
dc.contributor.authorBedir, Erdal
dc.date.accessioned2020-07-18T08:31:25Z
dc.date.available2020-07-18T08:31:25Z
dc.date.issued2020
dc.identifier.issn0378-8741
dc.identifier.issn1872-7573
dc.identifier.urihttps://doi.org/10.1016/j.jep.2020.112868
dc.identifier.urihttps://hdl.handle.net/11147/8789
dc.descriptionWOS: 000538156200035en_US
dc.descriptionPubMed: 32298751en_US
dc.description.abstractEthnopharmacological relevance: Several species of Ferula L. genus have been used in traditional Turkish medicine as aphrodisiac to treat male sexual dysfunction. Especially, roots and oleo gum resin of F. elaeochytris Korovin, F. communis L., F. assa-foetida L. and F. gummosa Boiss. were claimed to be used for aphrodisiac activity, menstrual regulation and treatment of gastric pain in Anatolia. Ferula L. is represented by 23 taxa in Turkey, 13 of which are endemic species. F. huber-morathii Pesmen (FHM), an endemic plant, is popularly known as "helizan, cagsir". Aim of the study: This study aimed to isolate sesquiterpenoids from the roots of Ferula huber-morathii (FHM) and to confirm their aphrodisiac potential in male rats. Material and methods: In a preliminary experiment, the effects of aqueous (H2O) and chloroform (CHCl3) extracts of FHM were tested for their potential aphrodisiac activities in male rats. Then, sesquiterpene derivatives were isolated from the active chloroform extract of FHM roots (FHM-R) and characterized (TLC, 1D, 2D NMR, HR-MS and CD). Moreover, some of the isolates with adequate quantities were evaluated for their possible aphrodisiac effects on male rats. Single doses (10 mg/kg BW) of sildenafil citrate (SC, positive control), gummosin, mogoltavidin, deacetylkellerin, ferukrin acetate with kellerin, elaeochytrin-A and ferutinin were administered or-ally by gavages to male Wistar albino rats. Mount latency (ML), mount frequency (MF), intromission latency (IL), intromission frequency (IF), ejaculation latency (EL) and postejaculatory interval (PEI) were studied. In addition, copulatory efficiency (CE) and intercopulatory efficiency (ICE) were calculated. Results: The preliminary experiment revealed that the chloroform extract was the main source of the active compounds as it showed the higher aphrodisiac activity while the aqueous extract was found to be inactive. Eleven sesquiterpene derivatives, viz. gummosin, mogoltavidin, farnesiferol A, deacetylkellerin, ferukrin acetate, kellerin, teuclatriol, feruhermonin C, ferutinin, elaeochytrin A and teferidin, were isolated from the FHM-CHCl3 extract. Oral administration of deacetylkellerin, elaeochytrin-A and ferutinin significantly increased MF and IF. The ML and IL were significantly reduced, and ejaculation latencies were prolonged. Administration of these sesquiterpenoids also reduced the PEI. The present results revealed that ferutinin was the most effective aph-rodisiac compound compared to other sesquiterpenoids. The results of 10 mg/kg of ferutinin are comparable to SC, the positive control. The results revealed that gummosin, mogoltavidin and ferukrin acetate with kellerin did not significantly alter the aphrodisiac parameters. Conclusions: This study has established that the CHCl3 extract of FHM root contains sesquiterpene derivatives, especially coumarin ethers and benzoic esters. Findings of the present study demonstrate that the chloroform extract and some of the sesquiterpene derivatives significantly stimulates sexual behavior in male rats, thus suggesting that F. huber-morathii possesses an aphrodisiac activity.en_US
dc.language.isoengen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.isversionof10.1016/j.jep.2020.112868en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFerulaen_US
dc.subjectSesquiterpeneen_US
dc.subjectCoumarinen_US
dc.subjectDaucaneen_US
dc.subjectSexual behavioren_US
dc.titleEvaluation of the potential aphrodisiac activity of sesquiterpenoids from roots of Ferula huber-morathii Pesmen in male ratsen_US
dc.typearticleen_US
dc.relation.journalJournal Of Ethnopharmacologyen_US
dc.contributor.departmentIzmir Institute of Technologyen_US
dc.identifier.volume257en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.cont.department-temp[Aydogan, Fadime; Baykan, Sura] Ege Univ, Fac Pharm, Dept Pharmaceut Bot, TR-35030 Izmir, Turkey; [Soliman, Gamal A.] Cairo Univ, Dept Pharmacol, Coll Vet Med, Giza 12211, Saudi Arabia; [Soliman, Gamal A.] Prince Sattam Bin Abdulaziz Univ, Coll Pharm, Dept Pharmacol, Al Kharj 11942, Saudi Arabia; [Yusufoglu, Hasan] Prince Sattam Bin Abdulaziz Univ, Coll Pharm, Dept Pharmacognosy, Al Kharj 11942, Saudi Arabia; [Bedir, Erdal] Izmir Inst Technol, Fac Engn, Dept Bioengn, TR-35430 Izmir, Turkeyen_US


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