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Secreted Wnt antagonists in leukemia: A road yet to be paved
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Wnt signaling has been a topic of research for many years for its diverse and fundamental functions in physiological (such as embryogenesis, organogenesis, proliferation, tissue repair and cellular differentiation) and pathological (carcinogenesis, congenital/genetic diseases, and tissue degeneration) processes. Wnt signaling pathway aberrations are associated with both solid tumors and hematological malignancies. Unregulated Wnt signaling observed in malignancies may be due to a wide spectrum of abnormalities, from mutations in the genes of key players to epigenetic modifications of Wnt antagonists. Of these, Wnt antagonists are gaining significant attention for their potential of being targets for treatment and inhibition of Wnt signaling. In this review, we discuss and summarize the significance of Wnt signaling antagonists in the pathogenesis and treatment of hematological malignancies.
- Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik 
- PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection 
- Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection 
- WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection