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dc.contributor.authorBalcı, Beste
dc.contributor.authorTop, Ayben
dc.date.accessioned2020-01-06T08:53:59Z
dc.date.available2020-01-06T08:53:59Z
dc.date.issued2018-04en_US
dc.identifier.citationBalcı, B., and Top, A. (2018). PEG and PEG-peptide based doxorubicin delivery systems containing hydrazone bond. Journal of Polymer Research, 25(4). doi:10.1007/s10965-018-1506-6en_US
dc.identifier.issn1022-9760
dc.identifier.urihttps://doi.org/10.1007/s10965-018-1506-6
dc.identifier.urihttps://hdl.handle.net/11147/7558
dc.description.abstractmPEG and mPEG-peptide based drug delivery systems were prepared by conjugating doxorubicin (DOX) to these carrier molecules via hydrazone bond. The peptide, AT1, with a sequence of CG3H6G3E served as mPEG and doxorubicin attachment site. Histidines were incorporated to the sequence to improve pH responsiveness of the carrier molecule. Hydrodynamic diameters (mean sizes) of mPEG-based drug delivery system (mPEG-HYD-DOX) were measured as 9 ± 0.5 and 7 ± 0.5 nm at pH 7.4 and pH 5.0, respectively. Mean size of the aggregates of the peptide containing drug delivery system, mPEG-AT1-DOX, was determined as 12 ± 2 nm at neutral pH. At pH 5.0, on the other hand, mPEG-AT1-DOX exhibited a size distribution between 20 and 100 nm centered at about 40 nm. Comparison of % DOX release values of the drug delivery systems obtained at pH 7.4 and pH 5.0 indicated that mPEG-AT1-DOX has enhanced pH sensitivity. DOX equivalent absolute IC50 values were obtained as 0.96 ± 0.51, 21.9 ± 5.9, and 5.55 ± 0.75 μg/mL for free DOX, mPEG-HYD-DOX, and mPEG-AT1-DOX, respectively. Considering more pronounced pH sensitivity and cytotoxicity of mPEG-AT1-DOX, the use of both pH responsive functional groups and acid cleavable chemical bond between the carrier molecule and drug can be a promising approach in the design of drug delivery systems for cancer therapy.en_US
dc.description.sponsorshipTUBITAK (112S554)en_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.isversionof10.1007/s10965-018-1506-6en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDoxorubicinen_US
dc.subjectHydrazone bonden_US
dc.subjectDrug delivery systemsen_US
dc.subjectpH sensorsen_US
dc.subjectPEGen_US
dc.subjectPolyethylene glycolsen_US
dc.subjectPeptidesen_US
dc.titlePEG and PEG-peptide based doxorubicin delivery systems containing hydrazone bonden_US
dc.typearticleen_US
dc.contributor.authorID0000-0003-0554-2506en_US
dc.contributor.iztechauthorBalcı, Beste
dc.contributor.iztechauthorTop, Ayben
dc.relation.journalJournal of Polymer Researchen_US
dc.contributor.departmentIzmir Institute of Technology. Chemical Engineeringen_US
dc.identifier.volume25en_US
dc.identifier.issue4en_US
dc.identifier.wosWOS:000428872700001
dc.identifier.scopusSCOPUS:2-s2.0-85044610355
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/SBAG/112S554
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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