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dc.contributor.authorTamburacı, Sedef
dc.contributor.authorTıhmınlıoğlu, Funda
dc.date.accessioned2019-12-24T12:56:18Z
dc.date.available2019-12-24T12:56:18Z
dc.date.issued2018-01en_US
dc.identifier.citationTamburacı, S., and Tıhmınlıoğlu, F. (2018). Novel poss reinforced chitosan composite membranes for guided bone tissue regeneration. Journal of Materials Science: Materials in Medicine, 29(1). doi:10.1007/s10856-017-6005-5en_US
dc.identifier.issn0957-4530
dc.identifier.urihttps://doi.org/10.1007/s10856-017-6005-5
dc.identifier.urihttps://hdl.handle.net/11147/7521
dc.description.abstractIn this study, novel composites membranes composed of chitosan matrix and polyhedral oligomeric silsesquioxanes (POSS) were fabricated by solvent casting method. The effect of POSS loading on the mechanical, morphological, chemical, thermal and surface properties, and cytocompatibility of composite membranes were investigated and observed by tensile test, atomic force microscopy (AFM), Fourier transform infrared spectroscopy (FTIR), thermal gravimetric analysis (TGA), protein adsorption assay, air/water contact angle analysis and WST-1 respectively. Swelling studies were also performed by water absorption capacity determination. Results showed that incorporation of Octa-TMA POSS® nanofiller to the chitosan matrix increased the surface roughness, protein adsorption and swelling capacity of membranes. The addition of POSS enhanced significantly the ultimate tensile strength and strain at break of the composite membranes up to 3 wt% POSS loaded samples. An increase of about 76% in tensile strength and of strain at break 1.28% was achieved for 3 wt% POSS loaded nanocomposite membranes compared with chitosan membranes. The presence of POSS filler into polymer matrix increased the plasma protein adsorption on the surface. Maximum protein capacity and swelling was obtained for 10 wt% loaded samples. High cell viability results were obtained with indirect extraction of chitosan/POSS composites. Besides, cell proliferation and ALP activity results showed that POSS incorporation significantly increased the ALP activity of Saos-2 cells cultured on chitosan membranes. This novel composite membranes with tunable properties could be considered as a potential candidate for guided bone regeneration applicationsen_US
dc.description.sponsorshipIzmir Institute of Technology (No.2011 İYTE02)en_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.isversionof10.1007/s10856-017-6005-5en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectComposite membranesen_US
dc.subjectPolyhedral oligomeric silsesquioxanesen_US
dc.subjectChitosanen_US
dc.subjectWater absorptionen_US
dc.subjectPolymersen_US
dc.titleNovel poss reinforced chitosan composite membranes for guided bone tissue regenerationen_US
dc.typearticleen_US
dc.contributor.authorID0000-0002-3715-8253en_US
dc.contributor.institutionauthorTamburacı, Sedef
dc.contributor.institutionauthorTıhmınlıoğlu, Funda
dc.relation.journalJournal of Materials Science: Materials in Medicineen_US
dc.contributor.departmentIzmir Institute of Technology. Chemical Engineeringen_US
dc.identifier.volume29en_US
dc.identifier.issue1en_US
dc.identifier.wosWOS:000424301800001
dc.identifier.scopusSCOPUS:2-s2.0-85037349177
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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