Now showing items 1-5 of 5
Multidrug resistance in chronic myeloid leukemia
Chronic myeloid leukemia (CML) is characterized by the accumulation of Philadelphia chromosome-positive (Ph+) myeloid cells. Ph+ cells occur via a reciprocal translocation between the long arms of chromosomes 9 and 22 ...
Therapeutic applications of bioactive sphingolipids in hematological malignancies
Sphingolipids are sphingosine-based lipid molecules that have important functions in cellular signal transduction and in a variety of cellular processes including proliferation, differentiation, programmed cell death ...
Therapeutic potential of targeting ceramide/glucosylceramide pathway in cancer
Sphingolipids including ceramides and its derivatives such as ceramide-1-phosphate, glucosylceramide (GlcCer), and sphingosine-1-phosphate are essential structural components of cell membranes. They now recognized as novel ...
An update on molecular biology and drug resistance mechanisms of multiple myeloma
Multiple myeloma (MM), a neoplasm of plasma cells, is the second most common hematological malignancy. Incidance rates increase after age 40. MM is most commonly seen in men and African-American population. There are several ...
Novel agents targeting bioactive sphingolipids for the treatment of cancer
(Bentham Science Publishers, 2013-01)
Sphingolipids are a class of lipids that have important functions in a variety of cellular processes such as, differentiation, proliferation, senescence, apoptosis and chemotherapeutic resistance. The most widely studied ...