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dc.contributor.authorGöktaş, Çağdaş
dc.contributor.authorYiğit, Hatice
dc.contributor.authorCoşacak, Mehmet İlyas
dc.contributor.authorAkgül, Bünyamin
dc.date.accessioned2018-01-26T11:20:36Z
dc.date.available2018-01-26T11:20:36Z
dc.date.issued2017-11
dc.identifier.citationGöktaş, Ç., Yiğit, H., Coşacak, M. İ., and Akgül, B. (2017). Differentially expressed tRNA-derived small RNAs co-sediment primarily with non-polysomal fractions in Drosophila. Genes, 8(11). doi:10.3390/genes8110333en_US
dc.identifier.issn2073-4425
dc.identifier.urihttp://doi.org/10.3390/genes8110333
dc.identifier.urihttp://hdl.handle.net/11147/6757
dc.description.abstractRecent studies point to the existence of poorly characterized small regulatory RNAs generated from mRNAs, rRNAs and tRNAs. To explore the subcellular location of tRNA-derived small RNAs, 0–1 and 7–8 h Drosophila embryos were fractionated on sucrose density gradients. Analysis of 12,553,921 deep-sequencing reads from unfractionated and fractionated Drosophila embryos has revealed that tRFs, which are detected mainly from the 5’ends of tRNAs, co-sediment with the non-polysomal fractions. Interestingly, the expression levels of a subset of tRFs change temporally following thematernal-to-zygotic transition in embryos. We detected non-polysomal association of tRFs in S2 cells as well. Differential tRF expression pattern points to developmental significance at the organismal level. These results suggest that tRFs are associated primarily with the non-polysomal complexes in Drosophila embryos and S2 cells.en_US
dc.description.sponsorshipScientific and Technical Research Council of Turkey (210T006)en_US
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relationinfo:eu-repo/grantAgreement/TUBITAK/TBAG/210T006en_US
dc.relation.isversionof10.3390/genes8110333en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDrosophilaen_US
dc.subjectPolysomeen_US
dc.subjectTRNAen_US
dc.subjectTRFen_US
dc.titleDifferentially expressed tRNA-derived small RNAs co-sediment primarily with non-polysomal fractions in Drosophilaen_US
dc.typearticleen_US
dc.contributor.authorIDTR37475en_US
dc.contributor.institutionauthorGöktaş, Çağdaş
dc.contributor.institutionauthorYiğit, Hatice
dc.contributor.institutionauthorCoşacak, Mehmet İlyas
dc.contributor.institutionauthorAkgül, Bünyamin
dc.relation.journalGenesen_US
dc.contributor.departmentİYTE, Fen Fakültesi, Moleküler Biyoloji ve Genetik Bölümüen_US
dc.identifier.volume8en_US
dc.identifier.issue11en_US
dc.identifier.wosWOS:000416800600043
dc.identifier.scopusSCOPUS:2-s2.0-85035003620
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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