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dc.contributor.authorAslanipour, Behnaz
dc.contributor.authorGülcemal, Derya
dc.contributor.authorNalbantsoy, Ayşe
dc.contributor.authorYusufoğlu, Hasan
dc.contributor.authorBedir, Erdal
dc.date.accessioned2018-01-02T13:31:19Z
dc.date.available2018-01-02T13:31:19Z
dc.date.issued2017-09
dc.identifier.citationAslanipour, B., Gülcemal, D., Nalbantsoy, A., Yusufoğlu, H., and Bedir, E. (2017). Cycloartane-type glycosides from Astragalus brachycalyx FISCHER and their effects on cytokine release and hemolysis. Phytochemistry Letters, 21, 66-73. doi:10.1016/j.phytol.2017.05.028en_US
dc.identifier.issn1874-3900
dc.identifier.urihttp://doi.org/10.1016/j.phytol.2017.05.028
dc.identifier.urihttp://hdl.handle.net/11147/6631
dc.description.abstractTwo new tridesmosidic cycloartane-type triterpene glycosides (1 and 2) were isolated from the methanolic extract of the roots of Astragalus brachycalyx FISCHER (A. brachycalyx) along with ten (3–12) known cycloartane-type triterpene glycosides. Structures of the new compounds were established as 3-O-β-D-xylopyranosyl-6-O-β-D-glucopyranosyl-16-O-β-D-glucopyranosyl-3β,6α,16β,24(S)-25-pentahydroxycycloartane (1), 3-O-[α-L-arabinopyranosyl-(1→2)-β-D-xylopyranosyl]-6-O-β-D-glucopyranosyl-16-O-β-D-glucopyranosyl-3β,6α,16β,24(S)-25-pentahydroxycycloartane (2), by using 1D and 2D-NMR techniques and mass spectrometry. In vitro immunomodulatory effects and hemolytic activities of the new saponins (1 and 2) and acetylated form of 1 (1a) were studied together with the BuOH and MeOH extracts of Astragalus brachycalyx. The results have proven that tridesmosidic Astragalus cycloartanes are noteworthy immunomodulatory compounds via induction of cytokine production, namely IL-2 and IFN-γ. The test compounds also resulted slight hemolysis at very high doses substantiating a safer profile compared to the positive control QS-21.en_US
dc.description.sponsorshipEge University Research Foundation (15-FBE-001)en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1016/j.phytol.2017.05.028en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAstragalus brachycalyxen_US
dc.subjectFabaceaeen_US
dc.subjectSaponinsen_US
dc.subjectCycloartaneen_US
dc.subjectCytokine stimulationen_US
dc.titleCycloartane-type glycosides from Astragalus brachycalyx FISCHER and their effects on cytokine release and hemolysisen_US
dc.typearticleen_US
dc.contributor.authorIDTR12161en_US
dc.contributor.institutionauthorBedir, Erdal
dc.relation.journalPhytochemistry Lettersen_US
dc.contributor.departmentIzmir Institute of Technology. Biotechnology and Bioengineeringen_US
dc.identifier.volume21en_US
dc.identifier.startpage66en_US
dc.identifier.endpage73en_US
dc.identifier.wosWOS:000414229300014
dc.identifier.scopusSCOPUS:2-s2.0-85020619227
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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