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dc.contributor.authorSaçar, Müşerref Duygu
dc.contributor.authorBağcı, Caner
dc.contributor.authorAllmer, Jens
dc.date.accessioned2017-06-13T08:27:27Z
dc.date.available2017-06-13T08:27:27Z
dc.date.issued2014-10
dc.identifier.citationSaçar, M.D., Bağcı, C., and Allmer, J. (2014). Computational prediction of MicroRNAs from toxoplasma gondii potentially regulating the hosts' gene expression. Genomics, Proteomics and Bioinformatics, 12(5), 228-238. doi:10.1016/j.gpb.2014.09.002en_US
dc.identifier.issn1672-0229
dc.identifier.urihttps://doi.org/10.1016/j.gpb.2014.09.002
dc.identifier.urihttp://hdl.handle.net/11147/5752
dc.description.abstractMicroRNAs (miRNAs) were discovered two decades ago, yet there is still a great need for further studies elucidating their genesis and targeting in different phyla. Since experimental discovery and validation of miRNAs is difficult, computational predictions are indispensable and today most computational approaches employ machine learning. Toxoplasma gondii, a parasite residing within the cells of its hosts like human, uses miRNAs for its post-transcriptional gene regulation. It may also regulate its hosts' gene expression, which has been shown in brain cancer. Since previous studies have shown that overexpressed miRNAs within the host are causal for disease onset, we hypothesized that T. gondii could export miRNAs into its host cell. We computationally predicted all hairpins from the genome of T. gondii and used mouse and human models to filter possible candidates. These were then further compared to known miRNAs in human and rodents and their expression was examined for T. gondii grown in mouse and human hosts, respectively. We found that among the millions of potential hairpins in T. gondii, only a few thousand pass filtering using a human or mouse model and that even fewer of those are expressed. Since they are expressed and differentially expressed in rodents and human, we suggest that there is a chance that T. gondii may export miRNAs into its hosts for direct regulation.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1016/j.gpb.2014.09.002en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHost interactionen_US
dc.subjectMicroRNAen_US
dc.subjectParasiteen_US
dc.subjectToxoplasma gondiien_US
dc.titleComputational prediction of MicroRNAs from toxoplasma gondii potentially regulating the hosts' gene expressionen_US
dc.typearticleen_US
dc.contributor.authorIDTR114170en_US
dc.contributor.authorIDTR107974en_US
dc.contributor.institutionauthorSaçar, Müşerref Duygu
dc.contributor.institutionauthorBağcı, Caner
dc.contributor.institutionauthorAllmer, Jens
dc.relation.journalGenomics, Proteomics and Bioinformaticsen_US
dc.contributor.departmentİYTE, Fen Fakültesi, Moleküler Biyoloji ve Genetik Bölümüen_US
dc.identifier.volume12en_US
dc.identifier.issue5en_US
dc.identifier.startpage228en_US
dc.identifier.endpage238en_US
dc.identifier.scopusSCOPUS:2-s2.0-84922563717
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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