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dc.contributor.authorMolin, Mikael
dc.contributor.authorDemir, Ayşe Banu
dc.date.accessioned2017-04-27T13:30:46Z
dc.date.available2017-04-27T13:30:46Z
dc.date.issued2014
dc.identifier.citationMolin, M., and Demir, A. B. (2014). Linking peroxiredoxin and vacuolar-ATPase functions in calorie restriction-mediated life span extension. International Journal of Cell Biology. doi:10.1155/2014/913071en_US
dc.identifier.issn1687-8876
dc.identifier.urihttp://doi.org/10.1155/2014/913071
dc.identifier.urihttp://hdl.handle.net/11147/5428
dc.description.abstractCalorie restriction (CR) is an intervention extending the life spans of many organisms. The mechanisms underlying CR-dependent retardation of aging are still poorly understood. Despite mechanisms involving conserved nutrient signaling pathways proposed, few target processes that can account for CR-mediated longevity have so far been identified. Recently, both peroxiredoxins and vacuolar-ATPases were reported to control CR-mediated retardation of aging downstream of conserved nutrient signaling pathways. In this review, we focus on peroxiredoxin-mediated stress-defence and vacuolar-ATPase regulated acidification and pinpoint common denominators between the two mechanisms proposed for how CR extends life span. Both the activities of peroxiredoxins and vacuolar-ATPases are stimulated upon CR through reduced activities in conserved nutrient signaling pathways and both seem to stimulate cellular resistance to peroxide-stress. However, whereas vacuolar-ATPases have recently been suggested to control both Ras-cAMP-PKA- and TORC1-mediated nutrient signaling, neither the physiological benefits of a proposed role for peroxiredoxins in H 2O2-signaling nor downstream targets regulated are known. Both peroxiredoxins and vacuolar-ATPases do, however, impinge on mitochondrial iron-metabolism and further characterization of their impact on iron homeostasis and peroxide-resistance might therefore increase our understanding of the beneficial effects of CR on aging and age-related diseases. © 2014 Mikael Molin and Ayse Banu Demir.en_US
dc.language.isoengen_US
dc.publisherHindawi Publishing Corporationen_US
dc.relation.isversionof10.1155/2014/913071en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdenosine triphosphataseen_US
dc.subjectPeroxiredoxinen_US
dc.subjectReactive oxygen metaboliteen_US
dc.subjectCalorie restrictionen_US
dc.subjectFree radicalen_US
dc.subjectHydrogen peroxideen_US
dc.subjectIron metabolismen_US
dc.titleLinking peroxiredoxin and vacuolar-ATPase functions in calorie restriction-mediated life span extensionen_US
dc.typereviewen_US
dc.contributor.institutionauthorDemir, Ayşe Banu
dc.relation.journalInternational Journal of Cell Biologyen_US
dc.contributor.departmentİYTE, Fen Fakültesi, Moleküler Biyoloji ve Genetik Bölümüen_US
dc.identifier.scopusSCOPUS:2-s2.0-84896880111
dc.relation.publicationcategoryDiğeren_US


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