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dc.contributor.authorŞenarısoy, Müge
dc.contributor.authorCantürk, Pakize
dc.contributor.authorZencir, Sevil
dc.contributor.authorBaran, Yusuf
dc.contributor.authorTopçu, Zeki
dc.date.accessioned2017-04-19T11:38:34Z
dc.date.available2017-04-19T11:38:34Z
dc.date.issued2013
dc.identifier.citationŞenarısoy, M., Cantürk, P., Zencir, S., Baran, Y., and Topçu, Z. (2013). Gossypol interferes with both type I and Type II topoisomerase activities without generating strand breaks. Cell Biochemistry and Biophysics, 66(1), 199-204. doi:10.1007/s12013-012-9468-5en_US
dc.identifier.issn1085-9195
dc.identifier.urihttps://doi.org/10.1007/s12013-012-9468-5
dc.identifier.urihttp://hdl.handle.net/11147/5350
dc.description.abstractA considerable number of agents with chemotherapeutic potentials reported over the past years were shown to interfere with the reactions of DNA topoisomerases, the essential enzymes that regulate conformational changes in DNA topology. Gossypol, a naturally occurring bioactive phytochemical is a chemopreventive agent against various types of cancer cell growth with a reported activity on mammalian topoisomerase II. The compounds targeting topoisomerases vary in their mode of action; class I compounds act by stabilizing covalent topoisomerase-DNA complexes resulting in DNA strand breaks while class II compounds interfere with the catalytic function of topoisomerases without generating strand breaks. In this study, we report Gossypol as the interfering agent with type I topoisomerases as well. We also carried out an extensive set of assays to analyze the type of interference manifested by Gossypol on DNA topoisomerases. Our results strongly suggest that Gossypol is a potential class II inhibitor as it blocked DNA topoisomerase reactions with no consequently formed strand breaks.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TBAG-108T548)en_US
dc.language.isoengen_US
dc.publisherHumana Pressen_US
dc.relationinfo:eu-repo/grantAgreement/TUBITAK/TBAG/108T548en_US
dc.relation.isversionof10.1007/s12013-012-9468-5en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnticancer drug researchen_US
dc.subjectDNA strand breaksen_US
dc.subjectDNA topoisomerasesen_US
dc.subjectGossypolen_US
dc.subjectGyrase inhibitoren_US
dc.titleGossypol interferes with both type I and Type II topoisomerase activities without generating strand breaksen_US
dc.typearticleen_US
dc.contributor.authorIDTR119193en_US
dc.contributor.institutionauthorBaran, Yusuf
dc.relation.journalCell Biochemistry and Biophysicsen_US
dc.contributor.departmentİYTE, Fen Fakültesi, Moleküler Biyoloji ve Genetik Bölümüen_US
dc.identifier.volume66en_US
dc.identifier.issue1en_US
dc.identifier.startpage199en_US
dc.identifier.endpage204en_US
dc.identifier.wosWOS:000317860900023
dc.identifier.scopusSCOPUS:2-s2.0-84876183776
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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