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dc.contributor.authorSunay, Özgür
dc.contributor.authorCan, Geylani
dc.contributor.authorÇakır, Zeynep
dc.contributor.authorDenek, Ziya
dc.contributor.authorKozanoǧlu, İlknur
dc.contributor.authorErbil, Güven
dc.contributor.authorYılmaz, Mustafa
dc.contributor.authorBaran, Yusuf
dc.date.accessioned2017-04-03T08:16:29Z
dc.date.available2017-04-03T08:16:29Z
dc.date.issued2013-06
dc.identifier.citationSunay, Ö., Can, G., Çakır, Z., Denek, Z., Kozanoğlu, İ., Erbil, G., Yılmaz, M., and Baran, Y. (2013). Autologous rabbit adipose tissue-derived mesenchymal stromal cells for the treatment of bone injuries with distraction osteogenesis. Cytotherapy, 15(6), 690-702. doi:10.1016/j.jcyt.2013.02.004en_US
dc.identifier.issn1465-3249
dc.identifier.urihttps://doi.org/10.1016/j.jcyt.2013.02.004
dc.identifier.urihttp://hdl.handle.net/11147/5197
dc.description.abstractBackground aims: Adipose tissue-derived mesenchymal stromal cells (MSCs) have a higher capacity for proliferation and differentiation compared with other cell lineages. Although distraction osteogenesis is the most important therapy for treating bone defects, this treatment is restricted in many situations. The aim of this study was to examine the therapeutic potential of adipose tissue-derived MSCs and osteoblasts differentiated from adipose tissue-derived MSCs in the treatment of bone defects. Methods: Bone defects were produced in the tibias of New Zealand rabbits that had previously undergone adipose tissue extraction. Tibial osteotomy was performed, and a distractor was placed on the right leg of the rabbits. The rabbits were placed in control (group I), stem cell (group II) and osteoblast-differentiated stem cell (group III) treatment groups. The rabbits were sacrificed, and the defect area was evaluated by radiologic, biomechanical and histopathologic tests to examine the therapeutic effects of adipose tissue-derived MSCs. Results: Radiologic analyses revealed that callus density and the ossification rate increased in group III compared with group I and group II. In biomechanical tests, the highest ossification rate was observed in group III. Histopathologic studies showed that the quality of newly formed bone and the number of cells active in bone formation were significantly higher in group III rabbits compared with group I and group II rabbits. Conclusions: These data reveal that osteoblasts differentiated from adipose tissue-derived MSCs shorten the consolidation period of distraction osteogenesis. Stem cells could be used as an effective treatment for bone defects.en_US
dc.description.sponsorshipDokuz Eylul University; Turkish Academy of Sciences, Outstanding Young Investigator Programmeen_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1016/j.jcyt.2013.02.004en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFACSen_US
dc.subjectBone defectsen_US
dc.subjectDistraction osteogenesisen_US
dc.subjectAdipose tissueen_US
dc.subjectMesenchymal stromal cellsen_US
dc.titleAutologous rabbit adipose tissue-derived mesenchymal stromal cells for the treatment of bone injuries with distraction osteogenesisen_US
dc.typearticleen_US
dc.contributor.authorIDTR119193en_US
dc.contributor.institutionauthorCan, Geylani
dc.contributor.institutionauthorÇakır, Zeynep
dc.contributor.institutionauthorBaran, Yusuf
dc.relation.journalCytotherapyen_US
dc.contributor.departmentIzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.volume15en_US
dc.identifier.issue6en_US
dc.identifier.startpage690en_US
dc.identifier.endpage702en_US
dc.identifier.wosWOS:000319032800008
dc.identifier.scopusSCOPUS:2-s2.0-84877294810
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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