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dc.contributor.authorAllmer, Jens
dc.date.accessioned2017-02-06T13:41:45Z
dc.date.available2017-02-06T13:41:45Z
dc.date.issued2012-01
dc.identifier.citationAllmer, J. (2012). Existing bioinformatics tools for the quantitation of post-translational modifications. Amino Acids, 42(1), 129-138. doi:10.1007/s00726-010-0614-3en_US
dc.identifier.issn0939-4451
dc.identifier.urihttp://doi.org/10.1007/s00726-010-0614-3
dc.identifier.urihttp://hdl.handle.net/11147/4795
dc.description.abstractMass spectrometry (MS)-based proteomics, by itself, is a vast and complex area encompassing various mass spectrometers, different spectra, and search result representations. When the aim is quantitation performed in different scanning modes at different MS levels, matters become additionally complex. Quantitation of post-translational modifications (PTM) represents the greatest challenge among these endeavors. Many different approaches to quantitation have been described and some of these can be directly applied to the quantitation of PTMs. The amount of data produced via MS, however, makes manual data interpretation impractical. Therefore, specialized software tools meet this challenge. Any software currently able to quantitate differentially labeled samples may theoretically be adapted to quantitate differential PTM expression among samples as well. Due to the heterogeneity of mass spectrometry-based proteomics; this review will focus on quantitation of PTM using liquid chromatography followed by one or more stages of mass spectrometry. Currently available free software, which either allow analysis of PTM or are easily adaptable for this purpose, is briefly reviewed in this paper. Selected studies, especially those related to phosphoproteomics, shall be used to highlight the current ability to quantitate PTMs. © Springer-Verlag 2010en_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.isversionof10.1007/s00726-010-0614-3en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLC-MSen_US
dc.subjectPost-translational modificationen_US
dc.subjectPTMen_US
dc.subjectQuantificationen_US
dc.titleExisting bioinformatics tools for the quantitation of post-translational modificationsen_US
dc.typeconferenceObjecten_US
dc.contributor.authorIDTR107974en_US
dc.contributor.institutionauthorAllmer, Jens
dc.relation.journalAmino Acidsen_US
dc.contributor.departmentİYTE, Fen Fakültesi, Moleküler Biyoloji ve Genetik Bölümüen_US
dc.identifier.volume42en_US
dc.identifier.issue1en_US
dc.identifier.startpage129en_US
dc.identifier.endpage138en_US
dc.identifier.wosWOS:000298644600010
dc.identifier.scopusSCOPUS:2-s2.0-84860235700
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US


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