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Antiproliferative activity of (R)-4 '-methylklavuzon on hepatocellular carcinoma cells and EpCAM(+)/CD133(+) cancer stem cells via SIRT1 and Exportin-1 (CRM1) inhibition
Cytotoxic effects of (R)-4'-methylklavuzon were investigated on hepatocellular carcinoma cells (HuH-7 and HepG2) and HuH-7 EpCAM(+)/CD133(+) cancer stem cells. IC50 of (R)-4'-methylklavuzon was found as 1.25 mu M for HuH-7 ...
Development of a water-soluble 3-formylBODIPY dye for fluorogenic sensing and cell imaging of sulfur dioxide derivatives
A new water-soluble, highly fluorogenic 3-formylBODIPY dye that enables the sensing of SO2 derivatives in aqueous buffers and cancer cells is reported. The quaternary ammonium group appended through the mesa-position of ...
Fluorescein propiolate: a propiolate- decorated fluorescent probe with remarkable selectivity towards cysteine
(Royal Society of Chemistry, 2019)
A fluorescent probe decorated with an alkynyl ester unit (e.g. propiolate) displayed a selective turn-on type fluorescent response towards cysteine. Following a sequential addition-cyclisation pathway mediated by the ...