Now showing items 1-5 of 5
Differentiation of normal and cancer cell adhesion on custom designed protein nanopatterns
(American Chemical Society, 2015-08-12)
Cell adhesion to the extracellular matrix is deregulated in metastasis. However, traditional surfaces used to study cell adhesion do not faithfully mimic the in vivo microenvironment. Electron beam lithography (EBL) is ...
Fabrication of 3D Controlled in vitro Microenvironments
Microfluidics-based lab-on-a-chips have many advantages, one of which is to provide physiologically relevant settings for cell biology experiments. Thus there is an ever increasing interest in their fabrication. Our goal ...
Invadopodia: Proteolytic feet of cancer cells
The leading cause of death in cancer patients is metastasis. Invasion is an integral part of metastasis and is carried out by proteolytic structures called invadopodia at the cellular level. In this introductory review, ...
Micrometer scale spacings between fibronectin nanodots regulate cell morphology and focal adhesions
(IOP Publishing, 2014-06)
Cell adhesion to extracellular matrix is an important process for both health and disease states. Surface protein patterns that are topographically flat, and do not introduce other chemical, topographical or rigidity related ...
Cellular distribution of invadopodia is regulated by nanometer scale surface protein patterns
Invadopodia are proteolytic structures formed by cancer cells. It is not known whether their cellular distribution can be regulated by the organization of the extracellular matrix or the organization of the golgi complex ...