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Methionine sulfoxide reduction and the aging process

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info:eu-repo/semantics/openAccess

Date

2007-04

Author

Koç, Ahmet
Gladyshev, Vadim N.

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Citation

Koç, A., and Gladyshev, V. N. (2007). Methionine sulfoxide reduction and the aging process. Annals of the New York Academy of Sciences, 1100, 383-386. doi:10.1196/annals.1395.042

Abstract

Aging has been described for multicellular and asymmetrically dividing organisms, but the mechanisms are poorly understood. Oxidation of proteins is considered to be one of the major factors that leads to aging. Oxidative damage to proteins results in the oxidation of certain amino acid residues, among which oxidation of sulfur-containing amino acids, methionine and cysteine, is notable because of the susceptibility of these residues to damage, and occurrence of repair mechanisms. Methionine sulfoxide reductases, MsrA and MsrB, are thioredoxin-dependent oxidoreductases that reduce oxidized forms of methionine, methionine sulfoxides, in a stereospecific manner. These enzymes are present in all cell types and have shown to be regulating life spans in mammals, insects, and yeast. Here, their roles in modulating yeast life span are discussed.

Source

Annals of the New York Academy of Sciences

Volume

1100

URI

http://doi.org/10.1196/annals.1395.042
http://hdl.handle.net/11147/2270

Collections

  • Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik [367]
  • Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection [4731]
  • WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection [4802]



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