Show simple item record

dc.contributor.authorBaran, Yusuf
dc.contributor.authorGür, Bala
dc.contributor.authorKaya, Pelin
dc.contributor.authorUral, Ali Uğur
dc.contributor.authorAvcu, Ferit
dc.contributor.authorGündüz, Ufuk
dc.date.accessioned2016-08-05T13:56:31Z
dc.date.available2016-08-05T13:56:31Z
dc.date.issued2007-12
dc.identifier.citationBaran, Y., Gür, B., Kaya, P., Ural, A. U., Avcu, F., and Gündüz, G. (2007). Upregulation of multi drug resistance genes in doxorubicin resistant human acute myelogeneous leukemia cells and reversal of the resistance. Hematology, 12(6), 511-517. doi:10.1080/10245330701562535en_US
dc.identifier.issn1024-5332
dc.identifier.urihttp://doi.org/10.1080/10245330701562535
dc.identifier.urihttp://hdl.handle.net/11147/2059
dc.description.abstractThe major problem in the treatment of acute myeloid leukemia (AML) patients results from multidrug resistance to administered anticancer agents. Drug resistance proteins, MDR1 and MRP1, which work as drug efflux pumps, can mediate the multidrug resistance of human leukemia cells. In this study, the mechanisms of resistance to doxorubicin-induced cell death in human HL60 AML cells were examined. Continuous exposure of cells to step-wise increasing concentrations of doxorubicin resulted in the selection of HL60/DOX cells, which expressed about 10.7-fold resistance as compared to parental sensitive cells. The expression analyses of MRP1 and MDR1 drug efflux proteins in doxorubicin-sensitive and -resistant HL60 cells revealed that there was an upregulation of MRP1 gene in HL60/DOX cells as compared to parental sensitive cells. On the other hand, while there was no expression of MDR1 gene in parental cells, the expression of MDR1 gene was upregulated in HL60/DOX cells. HL60/DOX cells also showed cross-resistance to cytosine arabinoside (Ara-c). This resistance was reversed by a combination therapy of Ara-c and cyclosporine A. However, the expression levels of CD15 and CD16 surface markers were significantly decreased in HL60/DOX cells.en_US
dc.description.sponsorshipDPT-07-02-K120540-14en_US
dc.language.isoengen_US
dc.publisherTaylor & Francisen_US
dc.relation.isversionof10.1080/10245330701562535en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAMLen_US
dc.subjectCytosine arabinosideen_US
dc.subjectDoxorubicinen_US
dc.subjectMultidrug resistanceen_US
dc.subjectMDR1en_US
dc.subjectMRP1en_US
dc.titleUpregulation of multi drug resistance genes in doxorubicin resistant human acute myelogeneous leukemia cells and reversal of the resistanceen_US
dc.typearticleen_US
dc.contributor.authorIDTR119193en_US
dc.contributor.institutionauthorBaran, Yusuf
dc.relation.journalHematologyen_US
dc.contributor.departmentIzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.volume12en_US
dc.identifier.issue6en_US
dc.identifier.startpage511en_US
dc.identifier.endpage517en_US
dc.identifier.wosWOS:000251645500008
dc.identifier.scopusSCOPUS:2-s2.0-35748937651
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record