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dc.contributor.authorBayraktar, Oğuz
dc.contributor.authorMalay, Özge
dc.contributor.authorÖzgarip, Yarkın
dc.contributor.authorBatıgün, Ayşegül
dc.date.accessioned2016-07-28T11:41:46Z
dc.date.available2016-07-28T11:41:46Z
dc.date.issued2005-08
dc.identifier.citationBayraktar, O., Malay, O., Özgarip, Y., and Batigün, A. (2005). Silk fibroin as a novel coating material for controlled release of theophylline. Silk fibroin as a novel coating material for controlled release of theophylline, 60(3), 373-381. doi:10.1016/j.ejpb.2005.02.002en_US
dc.identifier.issn0939-6411
dc.identifier.urihttp://doi.org/10.1016/j.ejpb.2005.02.002
dc.identifier.urihttp://hdl.handle.net/11147/2004
dc.description.abstractThe aim of this study was to explore potential use of the silk fibroin (SF) as an aqueous coating material for theophylline tablets. We have examined the film forming and coating properties of heat-treated fibroin, SF solution having different amounts of polyethylene glycol (PEG) and 1-ethyl-3-(3-dimethyl aminopropyl)carbodiimide (EDC) cross-linked SF. Heat-treated SF material possessed a brittle structure, which resulted in poor film forming and coating properties. The optimum PEG amount in SF solution was determined as 17% (by weight) for an acceptable film forming and zero order release profile. EDC cross-linked SF has shown a very good film forming and coating property with a potential for sustaining the drug release from coated theophylline tablets. Dissolution data for coated theophylline tablets were analyzed using Ritger and Peppas equation to describe the mechanism of drug release. Drug release from the EDC coated tablets followed zero-order kinetics. Release rate constants were found to be 0.26, 0.19, 0.16% min-1 for single-coated, double coated, and triple coated tablets, respectively. These results clearly demonstrated that silk fibroin has high utility as a novel aqueous coating material for controlled release products.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1016/j.ejpb.2005.02.002en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAqueous coatingen_US
dc.subjectControlled releaseen_US
dc.subjectCross-linkingen_US
dc.subjectSilk fibroinen_US
dc.subjectTheophyllineen_US
dc.titleSilk fibroin as a novel coating material for controlled release of theophyllineen_US
dc.typearticleen_US
dc.contributor.authorIDTR131394en_US
dc.contributor.iztechauthorBayraktar, Oğuz
dc.contributor.iztechauthorMalay, Özge
dc.contributor.iztechauthorÖzgarip, Yarkın
dc.contributor.iztechauthorBatıgün, Ayşegül
dc.relation.journalEuropean Journal of Pharmaceutics and Biopharmaceuticsen_US
dc.contributor.departmentIzmir Institute of Technology. Chemical Engineeringen_US
dc.identifier.volume60en_US
dc.identifier.issue3en_US
dc.identifier.startpage373en_US
dc.identifier.endpage381en_US
dc.identifier.wosWOS:000230781800006
dc.identifier.scopusSCOPUS:2-s2.0-21544448601
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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