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dc.contributor.authorBaskan, Oznur
dc.contributor.authorKaradas, Ozge
dc.contributor.authorMese, Gulistan
dc.contributor.authorOzcivici, Engin
dc.date.accessioned2021-02-12T18:47:30Z
dc.date.available2021-02-12T18:47:30Z
dc.date.issued2020
dc.identifier.issn1574-888X
dc.identifier.issn2212-3946
dc.identifier.urihttps://doi.org/10.2174/1574888X14666191212155647
dc.identifier.urihttps://hdl.handle.net/11147/10213
dc.descriptionbaskan, oznur/0000-0003-2766-2381; Karadas, Ozge/0000-0002-1956-8080; Ozcivici, Engin/0000-0003-4464-0475en_US
dc.descriptionPubMed: 31830894en_US
dc.description.abstractPersistent and transient mechanical loads can act as biological signals on all levels of an organism. It is therefore not surprising that most cell types can sense and respond to mechanical loads, similar to their interaction with biochemical and electrical signals. The presence or absence of mechanical forces can be an important determinant of form, function and health of many tissue types. Along with naturally occurring mechanical loads, it is possible to manipulate and apply external physical loads on tissues in biomedical sciences, either for prevention or treatment of catabolism related to many factors, including aging, paralysis, sedentary lifestyles and spaceflight. Mechanical loads consist of many components in their applied signal form such as magnitude, frequency, duration and intervals. Even though high magnitude mechanical loads with low frequencies (e.g. running or weight lifting) induce anabolism in musculoskeletal tissues, their applicability as anabolic agents is limited because of the required compliance and physical health of the target population. On the other hand, it is possible to use low magnitude and high frequency (e.g. in a vibratory form) mechanical loads for anabolism as well. Cells, including stem cells of the musculoskeletal tissue, are sensitive to high frequency, low-intensity mechanical signals. This sensitivity can be utilized not only for the targeted treatment of tissues, but also for stem cell expansion, differentiation and biomaterial interaction in tissue engineering applications. In this review, we reported recent advances in the application of low-intensity vibrations on stem and progenitor cell populations. Modulation of cellular behavior with low-intensity vibrations as an alternative or complementary factor to biochemical and scaffold induced signals may represent an increase of capabilities in studies related to tissue engineering.en_US
dc.description.sponsorshipScientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [215S862]; Turkish Academy of SciencesTurkish Academy of Sciencesen_US
dc.description.sponsorshipFinancial support from The Scientific and Technological Research Council of Turkey (215S862 - EO) and Turkish Academy of Sciences (Young Investigator Award - EO) is gratefully acknowledged.en_US
dc.language.isoengen_US
dc.publisherBENTHAM SCIENCE PUBL LTDen_US
dc.relation.isversionof10.2174/1574888X14666191212155647en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectStem cellen_US
dc.subjectvibrationsen_US
dc.subjectbiomechanicsen_US
dc.subjectmechanobiologyen_US
dc.subjecttissue engineeringen_US
dc.subjectprogenitor cell populationsen_US
dc.titleApplicability of Low-intensity Vibrations as a Regulatory Factor on Stem and Progenitor Cell Populationsen_US
dc.typereviewen_US
dc.typereviewen_US
dc.relation.journalCurrent Stem Cell Research & Therapyen_US
dc.contributor.departmentIzmir Isntitute of Technologyen_US
dc.identifier.volume15en_US
dc.identifier.issue5en_US
dc.identifier.startpage391en_US
dc.identifier.endpage399en_US
dc.identifier.wosWOS:000552079900002
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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