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Identification of mitochondrial electron transport chain mutations that effect ageing
(Izmir Institute of Technology, 2009)
Aging can be defined as the loss of cell functionality by accumulation of deleterious effects. Mitochondrial electron transport chain (ETC) is the main site for reactive oxygen species (ROS) production. According to free ...
The roles of thiol oxidoreductases in yeast replicative aging
Thiol-based redox reactions are involved in the regulation of a variety of biological functions, such as protection against oxidative stress, signal transduction and protein folding. Some proteins involved in redox regulation ...
Functional analysis of free methionine-R-sulfoxide reductase from saccharomyces cerevisiae
(American Society for Biochemistry and Molecular Biology, 2009-02)
Methionine sulfoxide reductases (Msrs) are oxidoreductases that catalyze thiol-dependent reduction of oxidized methionines. MsrA and MsrB are the best known Msrs that repair methionine S-sulfoxide (Met-S-SO) and ...
Identification of respiratory chain gene mutations that shorten replicative life span in yeast
Aging is the progressive accumulation of alterations in cells that elevates the risk of death. The mitochondrial theory of aging postulates that free radicals produced by the mitochondrial respiratory system contribute to ...