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Browsing by Author "Yalçın Özuysal, Özden"
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Antagonistic roles of Notch and p63 in controlling mammary epithelial cell fates
Yalçın Özuysal, Özden; Fiche, M.; Guitierrez, M.; Wagner, K. U.; Raffoul, W.; Brisken, C. (Nature Publishing Group, 2010-10)The breast epithelium has two major compartments, luminal and basal cells, that are established and maintained by poorly understood mechanisms. The p53 homolog, p63, is required for the formation of mammary buds, but its ... -
Biofabrication of cellular structures using weightlessness as a biotechnological tool
Anıl İnevi, Müge; Sarıgil, Öykü; Yaman, Sena; Yalçın Özuysal, Özden; Meşe, Gülistan; Tekin, Hüseyin Cumhur; Özçivici, Engin (IEEE, 2019)Gravity is an important biomechanical signal effecting the morphology and function of organisms. Reduction of gravitational forces, as experienced during spaceflight, cause alterations in the biological systems. Magnetic ... -
Biofabrication of in situ self assembled 3D cell cultures in a weightlessness environment generated using magnetic levitation
Anıl İnevi, Müge; Yaman, Sena; Arslan Yıldız, Ahu; Meşe, Gülistan; Yalçın Özuysal, Özden; Tekin, Hüseyin Cumhur; Özçivici, Engin (Nature Publishing, 2018-12)Magnetic levitation though negative magnetophoresis is a novel technology to simulate weightlessness and has recently found applications in material and biological sciences. Yet little is known about the ability of the ... -
CYR61-notch interaction during epithelial-to-mesenchymal transition, migration and invasion in breast cancer cells
İlhan, Mustafa (Izmir Institute of Technology, 2017-12)Notch signaling is one of the major pathways involved in development and tumorigenesis. Activated Notch is correlated with increased migration, invasion and epithelial-to-mesenchymal-transition (EMT) in breast cancer. ... -
Identification of novel Notch target genes that are mediators of Notch in inducing epithelial to mesenchymal transition and migration/invasion
Küçükköse, Cansu (Izmir Institute of Technology, 2016-06)Notch signaling has first been described in murine mammary gland by the proviral integration of mouse mammary tumor virus (MMTV) into the Notch4 locus (Int3 locus) which resulted expression of constitutively active form ... -
IRF6 is involved in the regulation of cell proliferation and transformation in MCF10A cells downstream of notch signaling
Zengin, Talip; Ekinci, Burcu; Küçükköse, Cansu; Yalçın Özuysal, Özden (Public Library of Science, 2015-07-10)IRF6, a member of Interferon Regulatory Factors (IRF) family, is involved in orofacial and epidermal development. In breast cancer cell lines ectopic expression of IRF6 reduces cell numbers suggesting a role as negative ... -
Perinatal exposure to bisphenol A increases adult mammary gland progesterone response and cell number
Ayyanan, Ayyakkannu; Laribi, Ouahiba; Schuepbach-Mallepell, Sonia; Schrick, Christina; Gutierrez, Maria; Tanos, Tamara; Lefebvre, Gregory; Rougemont, Jacques; Yalçın Özuysal, Özden; Brisken, Cathrin (The Endocrine Society, 2011-11)Bisphenol A [BPA, 2,2,-bis (hydroxyphenyl) propane] is one of the highest-volume chemicals produced worldwide. It is detected in body fluids of more than 90% of the human population. Originally synthesized as an estrogenic ... -
Progesterone and Wnt4 control mammary stem cells via myoepithelial crosstalk
Rajaram, Renuga Devi; Buric, Duje; Caikovski, Marian; Ayyanan, Ayyakkannu; Rougemont, Jacques; Shan, Jingdong; Vainio, Seppo J.; Yalçın Özuysal, Özden; Brisken, Cathrin (Wiley-Blackwell, 2015-03-04)Ovarian hormones increase breast cancer risk by poorly understood mechanisms. We assess the role of progesterone on global stem cell function by serially transplanting mouse mammary epithelia. Progesterone receptor (PR) ... -
Progesterone/RANKL is a major regulatory axis in the human breast
Tanos, Tamara; Sflomos, George; Echeverria, Pablo C.; Ayyanan, Ayyakkannu; Gutierrez, Maria; Delaloye, Jean-Francois; Raffoul, Wassim; Fiche, Maryse; Dougall, William; Schneider, Pascal; Yalçın Özuysal, Özden; Brisken, Cathrin (American Association for the Advancement of Science, 2013-04)Estrogens and progesterones are major drivers of breast development but also promote carcinogenesis in this organ. Yet, their respective roles and the mechanisms underlying their action in the human breast are unclear. ... -
Role of IRF6 in Notch regulated apoptosis, cell cycle and differentiation in breast epithelial cells
Ekinci, Burcu (Izmir Institute of Technology, 2015-12)Notch pathway, an evolutionarily conserved signaling, controls development, differentiation and proliferation. Notch1 and Notch4 activation caused mammary tumor formation showing an oncogenic effect. Overexpression of ... -
Role of SEMA6D in proliferation, epithelial-mesenchymal transition and migration of breast cancer cell lines
Şahi, Ece (Izmir Institute of Technology, 2017-12)Breast cancer is one of the most common cancer types around world and the second leading cause of cancer related deaths among women. Not the primary tumor but distant metastases are mainly the reason of deaths. For ...
