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Browsing by Author "Brisken, Cathrin"
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Perinatal exposure to bisphenol A increases adult mammary gland progesterone response and cell number
Ayyanan, Ayyakkannu; Laribi, Ouahiba; Schuepbach-Mallepell, Sonia; Schrick, Christina; Gutierrez, Maria; Tanos, Tamara; Lefebvre, Gregory; Rougemont, Jacques; Yalçın Özuysal, Özden; Brisken, Cathrin (The Endocrine Society, 2011-11)Bisphenol A [BPA, 2,2,-bis (hydroxyphenyl) propane] is one of the highest-volume chemicals produced worldwide. It is detected in body fluids of more than 90% of the human population. Originally synthesized as an estrogenic ... -
Progesterone and Wnt4 control mammary stem cells via myoepithelial crosstalk
Rajaram, Renuga Devi; Buric, Duje; Caikovski, Marian; Ayyanan, Ayyakkannu; Rougemont, Jacques; Shan, Jingdong; Vainio, Seppo J.; Yalçın Özuysal, Özden; Brisken, Cathrin (Wiley-Blackwell, 2015-03-04)Ovarian hormones increase breast cancer risk by poorly understood mechanisms. We assess the role of progesterone on global stem cell function by serially transplanting mouse mammary epithelia. Progesterone receptor (PR) ... -
Progesterone/RANKL is a major regulatory axis in the human breast
Tanos, Tamara; Sflomos, George; Echeverria, Pablo C.; Ayyanan, Ayyakkannu; Gutierrez, Maria; Delaloye, Jean-Francois; Raffoul, Wassim; Fiche, Maryse; Dougall, William; Schneider, Pascal; Yalçın Özuysal, Özden; Brisken, Cathrin (American Association for the Advancement of Science, 2013-04)Estrogens and progesterones are major drivers of breast development but also promote carcinogenesis in this organ. Yet, their respective roles and the mechanisms underlying their action in the human breast are unclear. ...
