Browsing Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik by Type "review"
Now showing items 1-20 of 23
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Algorithms for the de novo sequencing of peptides from tandem mass spectra
(Taylor & Francis, 2011-10)Proteomics is the study of proteins, their time- and location-dependent expression profiles, as well as their modifications and interactions. Mass spectrometry is useful to investigate many of the questions asked in ... -
Bioactive Sphingolipids in response to chemotherapy: A scope on Leukemias
(Bentham Science Publishers, 2011-05)Sphingolipids are major constituents of the cells with emerging roles in the regulation of cellular processes. Deregulation of sphingolipid metabolism is reflected as various pathophysiological conditions including metabolic ... -
Biotechnology for enhanced nutritional quality in plants
(Taylor & Francis, 2013-09)With almost 870 million people estimated to suffer from chronic hunger worldwide, undernourishment represents a major problem that severely affects people in developing countries. In addition to undernourishment, micronutrient ... -
Bisphosphonate treatment and radiotherapy in metastatic breast cancer
(Humana Press, 2008-09)Patients with advanced breast cancer frequently develop metastasis to bone. Bone metastasis results in intractable pain and high risk of pathologic fractures due to osteolysis. The treatment of breast cancer patients with ... -
Cell proliferation and cytotoxicity assays
(Bentham Science, 2016-11)Cell viability is defined as the number of healthy cells in a sample and proliferation of cells is a vital indicator for understanding the mechanisms in action of certain genes, proteins and pathways involved cell survival ... -
Comparative development of knowledge-based bioeconomy in the European Union and Turkey
(Informa Healthcare, 2014-09)Biotechnology, defined as the technological application that uses biological systems and living organisms, or their derivatives, to create or modify diverse products or processes, is widely used for healthcare, agricultural ... -
Flow cytometry: basic principles and applications
(Taylor & Francis, 2017-02)Flow cytometry is a sophisticated instrument measuring multiple physical characteristics of a single cell such as size and granularity simultaneously as the cell flows in suspension through a measuring device. Its working ... -
The importance of boron in biological systems
(Elsevier, 2018-01)Boron is an essential element for plants and probably essential for human and animal health. Boron has a broad range of physiological effects on biological systems at low concentrations, whereas it is toxic to at high ... -
The importance of protein profiling in the diagnosis and treatment of hematologic malignancies
(Galenos Publishing House, 2011)Proteins are important targets in cancer research because malignancy is associated with defects in cell protein machinery. Protein profiling is an emerging independent subspecialty of proteomics that is rapidly expanding ... -
Invadopodia: Proteolytic feet of cancer cells
(TÜBİTAK, 2014)The leading cause of death in cancer patients is metastasis. Invasion is an integral part of metastasis and is carried out by proteolytic structures called invadopodia at the cellular level. In this introductory review, ... -
Linking peroxiredoxin and vacuolar-ATPase functions in calorie restriction-mediated life span extension
(Hindawi Publishing Corporation, 2014)Calorie restriction (CR) is an intervention extending the life spans of many organisms. The mechanisms underlying CR-dependent retardation of aging are still poorly understood. Despite mechanisms involving conserved nutrient ... -
Major apoptotic mechanisms and genes involved in apoptosis
(Springer, 2016-07)As much as the cellular viability is important for the living organisms, the elimination of unnecessary or damaged cells has the opposite necessity for the maintenance of homeostasis in tissues, organs and the whole organism. ... -
Molecular mechanisms of drug resistance and its reversal in cancer
(Taylor & Francis, 2016-07)Chemotherapy is the main strategy for the treatment of cancer. However, the main problem limiting the success of chemotherapy is the development of multidrug resistance. The resistance can be intrinsic or acquired. The ... -
mRNA decay analysis in Drosophila melanogaster: Drug-induced changes in glutathione S-transferase D21 mRNA stability
(Elsevier, 2008)We have established an in vivo system to investigate mechanisms by which pentobarbital (PB), a psychoactive drug with a sedative effect, changes the rate of decay of gstD21 mRNA (encoding a Drosophila glutathione S-transferase). ... -
Multidrug resistance in chronic myeloid leukemia
(TÜBİTAK, 2014)Chronic myeloid leukemia (CML) is characterized by the accumulation of Philadelphia chromosome-positive (Ph+) myeloid cells. Ph+ cells occur via a reciprocal translocation between the long arms of chromosomes 9 and 22 ... -
Novel agents targeting bioactive sphingolipids for the treatment of cancer
(Bentham Science Publishers, 2013-01)Sphingolipids are a class of lipids that have important functions in a variety of cellular processes such as, differentiation, proliferation, senescence, apoptosis and chemotherapeutic resistance. The most widely studied ... -
Pathological hemichannels associated with human Cx26 mutations causing Keratitis-Ichthyosis-Deafness syndrome
(Elsevier, 2012-08)Abstract Connexin (Cx) proteins form intercellular gap junction channels by first assembling into single membrane hemichannels that then dock to connect the cytoplasm of two adjacent cells. Gap junctions are highly specialized ... -
Role of autophagy in the progression and suppression of leukemias
(Elsevier, 2012-03)Autophagy is a physiological process in which cellular components are degraded by the lysosomal machinery. Thereby, organelles are recycled and monomers are produced in order to maintain energy production. Current studies ... -
T cells in tumor microenvironment
(Springer, 2016-01)Tumors progress in a specific area, which supports its development, spreading or shrinking in time with the presence of different factors that effect the fate of the cancer cells. This specialized site is called “tumor ... -
Therapeutic applications of bioactive sphingolipids in hematological malignancies
(Wiley, 2010-10)Sphingolipids are sphingosine-based lipid molecules that have important functions in cellular signal transduction and in a variety of cellular processes including proliferation, differentiation, programmed cell death ...
