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dc.contributor.authorÖzçınar, Özge
dc.contributor.authorTağ, Özgür
dc.contributor.authorYusufoğlu, Hasan
dc.contributor.authorKıvçak, Bijen
dc.contributor.authorBedir, Erdal
dc.date.accessioned2020-01-22T13:12:51Z
dc.date.available2020-01-22T13:12:51Z
dc.date.issued2018-08en_US
dc.identifier.citationÖzçınar, Ö., Tağ, Ö., Yusufoğlu, H., Kıvçak, B., and Bedir, E. (2018). Biotransformation of ruscogenins by Cunninghamella blakesleeana NRRL 1369 and neoruscogenin by endophytic fungus Neosartorya hiratsukae. Phytochemistry, 152, 1-9. doi:10.1016/j.phytochem.2018.04.002en_US
dc.identifier.issn0031-9422
dc.identifier.urihttps://doi.org/10.1016/j.phytochem.2018.04.002
dc.identifier.urihttps://hdl.handle.net/11147/7616
dc.description.abstractBiotransformation of steroidal ruscogenins (neoruscogenin and ruscogenin) was carried out with Cunninghamella blakesleeana NRRL 1369 and endophytic fungus Neosartorya hiratsukae yielding mainly P450 monooxygenase products together with a glycosylated compound. Fermentation of ruscogenins (75:25, neoruscogenin-ruscogenin mixture) with C. blakesleeana yielded 8 previously undescribed hydroxylated compounds. Furthermore, microbial transformation of neoruscogenin by endophytic fungus N. hiratsukae afforded three previously undescribed neoruscogenin derivatives. While hydroxylation at C-7, C-12, C-14, C-21 with further oxidation at C-1 and C-7 were observed with C. blakesleeana, N. hiratsukae biotransformation provided C-7 and C-12 hydroxylated compounds along with C-12 oxidized and C-1(O) glycosylated derivatives. The structures of the metabolites were elucidated by 1-D (1H, 13C and DEPT135) and 2-D NMR (COSY, HMBC, HMQC, NOESY, ROESY) as well as HR-MS analyses.en_US
dc.description.sponsorshipTUBITAK (114Z958); Ege University Scientific Research Project 15ECZ011en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1016/j.phytochem.2018.04.002en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCunninghamella blakesleeanaen_US
dc.subjectNeoruscogeninen_US
dc.subjectBiotransformationen_US
dc.subjectNeosartorya hiratsukaeen_US
dc.subjectRuscogeninsen_US
dc.titleBiotransformation of ruscogenins by Cunninghamella blakesleeana NRRL 1369 and neoruscogenin by endophytic fungus Neosartorya hiratsukaeen_US
dc.typearticleen_US
dc.contributor.authorID0000-0003-1262-063Xen_US
dc.contributor.iztechauthorBedir, Erdal
dc.relation.journalPhytochemistryen_US
dc.contributor.departmentIzmir Institute of Technology. Biotechnology and Bioengineeringen_US
dc.identifier.volume152en_US
dc.identifier.startpage1en_US
dc.identifier.endpage9en_US
dc.identifier.wosWOS:000437383300001
dc.identifier.scopusSCOPUS:2-s2.0-85046022947
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/KBAG/114Z958
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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