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dc.contributor.authorAnıl İnevi, Müge
dc.contributor.authorYaman, Sena
dc.contributor.authorArslan Yıldız, Ahu
dc.contributor.authorMeşe, Gülistan
dc.contributor.authorYalçın Özuysal, Özden
dc.contributor.authorTekin, Hüseyin Cumhur
dc.contributor.authorÖzçivici, Engin
dc.date.accessioned2018-11-20T13:26:45Z
dc.date.available2018-11-20T13:26:45Z
dc.date.issued2018-12
dc.identifier.citationAnıl İnevi, M., Yaman, S., Arslan Yıldız, A., Meşe, G., Yalçın Özuysal, Ö., Tekin, H. C., and Özçivici, E. (2018). Biofabrication of in situ self assembled 3D cell cultures in a weightlessness environment generated using magnetic levitation. Scientific Reports, 8(1). doi:10.1038/s41598-018-25718-9en_US
dc.identifier.issn2045-2322
dc.identifier.urihttp://doi.org/10.1038/s41598-018-25718-9
dc.identifier.urihttp://hdl.handle.net/11147/6995
dc.description.abstractMagnetic levitation though negative magnetophoresis is a novel technology to simulate weightlessness and has recently found applications in material and biological sciences. Yet little is known about the ability of the magnetic levitation system to facilitate biofabrication of in situ three dimensional (3D) cellular structures. Here, we optimized a magnetic levitation though negative magnetophoresis protocol appropriate for long term levitated cell culture and developed an in situ 3D cellular assembly model with controlled cluster size and cellular pattern under simulated weightlessness. The developed strategy outlines a potential basis for the study of weightlessness on 3D living structures and with the opportunity for real-time imaging that is not possible with current ground-based simulated weightlessness techniques. The low-cost technique presented here may offer a wide range of biomedical applications in several research fields, including mechanobiology, drug discovery and developmental biology.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (215S862)en_US
dc.language.isoengen_US
dc.publisherNature Publishingen_US
dc.relationinfo:eu-repo/grantAgreement/TUBITAK/SBAG/215S862en_US
dc.relation.isversionof10.1038/s41598-018-25718-9en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectMagnetic levitationen_US
dc.subjectWeightlessnessen_US
dc.subjectBiofabricationen_US
dc.subject3D cellularen_US
dc.subjectCellsen_US
dc.titleBiofabrication of in situ self assembled 3D cell cultures in a weightlessness environment generated using magnetic levitationen_US
dc.typearticleen_US
dc.contributor.authorIDTR246425en_US
dc.contributor.authorIDTR12028en_US
dc.contributor.authorIDTR202132en_US
dc.contributor.authorIDTR109363en_US
dc.contributor.authorIDTR103812en_US
dc.contributor.authorIDTR243845en_US
dc.contributor.authorIDTR30296en_US
dc.contributor.institutionauthorAnıl İnevi, Müge
dc.contributor.institutionauthorYaman, Sena
dc.contributor.institutionauthorArslan Yıldız, Ahu
dc.contributor.institutionauthorMeşe, Gülistan
dc.contributor.institutionauthorYalçın Özuysal, Özden
dc.contributor.institutionauthorÖzçivici, Engin
dc.relation.journalScientific Reportsen_US
dc.contributor.departmentIzmir Institute of Technology. Biotechnology and Bioengineeringen_US
dc.contributor.departmentIzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.volume8en_US
dc.identifier.issue1en_US
dc.identifier.wosWOS:000431627300016
dc.identifier.scopusSCOPUS:2-s2.0-85046835734
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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