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dc.contributor.authorKiraz, Yağmur
dc.contributor.authorNeergheen-Bhujun, Vidushi S.
dc.contributor.authorRummun, Nawraj
dc.contributor.authorBaran, Yusuf
dc.date.accessioned2017-07-06T08:03:55Z
dc.date.available2017-07-06T08:03:55Z
dc.date.issued2016-02
dc.identifier.citationKiraz, Y., Neergheen-Bhujun, V.S., Rummun, N., and Baran, Y. (2016). Apoptotic effects of non-edible parts of Punica granatum on human multiple myeloma cells. Tumor Biology, 37(2), 1803-1815. doi:10.1007/s13277-015-3962-5en_US
dc.identifier.issn1010-4283
dc.identifier.urihttps://doi.org/10.1007/s13277-015-3962-5
dc.identifier.urihttp://hdl.handle.net/11147/5868
dc.description.abstractMultiple myeloma is of great concern since existing therapies are unable to cure this clinical condition. Alternative therapeutic approaches are mandatory, and the use of plant extracts is considered interesting. Punica granatum and its derived products were suggested as potential anticancer agents due to the presence of bioactive compounds. Thus, polypenolic-rich extracts of the non-edible parts of P. granatum were investigated for their antiproliferative and apoptotic effects on U266 multiple myeloma cells. We demonstrated that there were dose-dependent decreases in the proliferation of U266 cells in response to P. granatum extracts. Also, exposure to the extracts triggered apoptosis with significant increases in loss of mitochondrial membrane potential in U266 cells exposed to the leaves and stem extracts, while the flower extract resulted in slight increases in loss of MMP. These results were confirmed by Annexin-V analysis. These results documented the cytotoxic and apoptotic effects of P. granatum extracts on human U266 multiple myeloma cells via disruption of mitochondrial membrane potential and increasing cell cycle arrest. The data suggest that the extracts can be envisaged in cancer chemoprevention and call for further exploration into the potential application of these plant parts.en_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.isversionof10.1007/s13277-015-3962-5en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectApoptosisen_US
dc.subjectCytotoxicityen_US
dc.subjectMultiple myelomaen_US
dc.subjectPomegranateen_US
dc.subjectPolyphenol derivativeen_US
dc.subjectCancer preventionen_US
dc.titleApoptotic effects of non-edible parts of Punica granatum on human multiple myeloma cellsen_US
dc.typearticleen_US
dc.contributor.authorIDTR119193en_US
dc.contributor.institutionauthorKiraz, Yağmur
dc.contributor.institutionauthorBaran, Yusuf
dc.relation.journalTumor Biologyen_US
dc.contributor.departmentİYTE, Fen Fakültesi, Moleküler Biyoloji ve Genetik Bölümüen_US
dc.identifier.volume37en_US
dc.identifier.issue2en_US
dc.identifier.startpage1803en_US
dc.identifier.endpage1815en_US
dc.identifier.wosWOS:000374593300047
dc.identifier.scopusSCOPUS:2-s2.0-84941353994
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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