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dc.contributor.authorDoğan, Gamze
dc.contributor.authorBaşal, Güldemet
dc.contributor.authorBayraktar, Oğuz
dc.contributor.authorÖzyıldız, Figen
dc.contributor.authorUzel, Ataç
dc.contributor.authorErdoğan, İpek
dc.date.accessioned2017-06-16T12:10:37Z
dc.date.available2017-06-16T12:10:37Z
dc.date.issued2016-01
dc.identifier.citationDoğan, G., Başal, G., Bayraktar, O., Özyıldız, F., Uzel, A., and Erdoğan, İ. (2016). Bioactive Sheath/Core nanofibers containing olive leaf extract. Microscopy Research and Technique, 79(1), 38-49. doi:10.1002/jemt.22603en_US
dc.identifier.issn1059-910X
dc.identifier.urihttp://doi.org/10.1002/jemt.22603
dc.identifier.urihttp://hdl.handle.net/11147/5788
dc.description.abstractThis study aimed at producing silk fibroin (SF)/hyaluronic acid (HA) and olive leaf extract (OLE) nanofibers with sheath/core morphology by coaxial electrospinning method, determining their antimicrobial properties, and examining release profiles of OLE from these coaxial nanofibers. Optimum electrospinning process and solution parameters were determined to obtain uniform and bead-free coaxial nanofibers. Scanning electron microscopy and transmission electron microscopy (TEM) were used to characterize the morphology of the nanofibers. The antimicrobial activities of nanofibers were tested according to AATCC test method 100. Total phenolic content and total antioxidant activity were tested using in vitro batch release system. The quality and quantity of released components of OLE were determined by high-performance liquid chromatography. The changes in nanofibers were examined by Fourier-transform infrared spectroscopy. Uniform and bead-free nanofibers were produced successfully. TEM images confirmed the coaxial structure. OLE-loaded nanofibers demonstrated almost perfect antibacterial activities against both of gram-negative and gram-positive bacteria. Antifungal activity against C. albicans was rather poor. After a release period of 1 month, it was observed that ∼70-95% of the OLE was released from nanofibers and it was still bioactive. Overall results indicate that the resultant shell/core nanofibers have a great potential to be used as biomaterials.en_US
dc.description.sponsorshipDUAG Natural Productsen_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.isversionof10.1002/jemt.22603en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectActive agent release profileen_US
dc.subjectAntimicrobial activityen_US
dc.subjectAntioxidant activityen_US
dc.subjectCoaxial electrospinningen_US
dc.titleBioactive Sheath/Core nanofibers containing olive leaf extracten_US
dc.typearticleen_US
dc.contributor.institutionauthorErdoğan, İpek
dc.relation.journalMicroscopy Research and Techniqueen_US
dc.contributor.departmentIzmir Institute of Technology. Biotechnology and Bioengineeringen_US
dc.identifier.volume79en_US
dc.identifier.issue1en_US
dc.identifier.startpage38en_US
dc.identifier.endpage49en_US
dc.identifier.wosWOS:000369165100005
dc.identifier.scopusSCOPUS:2-s2.0-84954305946
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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