Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/5764
Title: Immobilization of alpha lipoic acid onto polysulfone membranes to suppress hemodialysis induced oxidative stress
Authors: Yaşar Mahlıçlı, Filiz
Altınkaya, Sacide
Yaşar Mahlıçlı, Filiz
Altınkaya, Sacide
Izmir Institute of Technology. Chemical Engineering
Keywords: Alpha lipoic acid
Antioxidant
Hemodialysis membranes
Reactive oxygen species
Self assembly of polyelectrolyte
Issue Date: Jan-2014
Publisher: Elsevier Ltd.
Source: Yaşar Mahlıçlı, F., and Alsoy Altınkaya, S. (2014). Immobilization of alpha lipoic acid onto polysulfone membranes to suppress hemodialysis induced oxidative stress. Journal of Membrane Science, 449, 27-37. doi:10.1016/j.memsci.2013.07.061
Abstract: Alpha-lipoic acid (ALA) immobilized polysulfone (PSF) hemodialysis membranes have been fabricated by the dry-wet phase inversion technique. The antioxidant properties of the membranes were evaluated in terms of inhibition of reactive oxygen species (ROS) in blood plasma, while their blood compatibilities were determined by quantitating plasma protein adsorption, platelet adhesion, activation and cytotoxicity to blood cells. The stability of ALA under typical hemodialysis conditions was improved by immobilization, and the greatest enhancement was achieved when it was sandwiched between two polyethyleneimine (PEI) layers. In vitro antioxidant activity measurements showed that ALA coated membranes are not only capable of reducing ROS levels in blood, protein adsorption and platelet activation on the membranes, but, can also prolong coagulation time. All membranes prepared were noncytotoxic to peripheral blood mononuclear cells. In addition, the high permeation rates of solutes through PSF membrane were not affected by ALA immobilization.
URI: http://doi.org/10.1016/j.memsci.2013.07.061
http://hdl.handle.net/11147/5764
ISSN: 0376-7388
1873-3123
Appears in Collections:Chemical Engineering / Kimya Mühendisliği
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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