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dc.contributor.authorSertkaya, Selda
dc.contributor.authorHamid, Syed Muhammad
dc.contributor.authorDilsiz, Nihat
dc.contributor.authorVarışlı, Lokman
dc.date.accessioned2017-05-18T12:56:51Z
dc.date.available2017-05-18T12:56:51Z
dc.date.issued2015-02
dc.identifier.citationSertkaya, S., Hamid, S. M., Dilsiz, N., and Varışlı, L. (2015). Decreased expression of EFS is correlated with the advanced prostate cancer. Tumor Biology, 36(2), 799-805. doi:10.1007/s13277-014-2703-5en_US
dc.identifier.issn1010-4283
dc.identifier.urihttp://doi.org/10.1007/s13277-014-2703-5
dc.identifier.urihttp://hdl.handle.net/11147/5556
dc.description.abstractProstate cancer is the most frequently diagnosed malignant neoplasm in men in the developed countries. Although the progression of prostate cancer and the processes of invasion and metastasis by tumor cells are comparatively well understood, the genes involved in these processes are not fully determined. Therefore, a common area of research interest is the identification of novel molecules that are involved in these processes. In the present study, we have used in silico and experimental approaches to compare the expression of embryonal Fyn-associated substrate (EFS) between normal prostate and prostate cancer. We showed that EFS expression is remarkably downregulated in prostate cancer cells, compared to normal prostate cells. We also found that decreased expression of EFS in prostate cancer cells is due to DNA methylation. In addition, we showed that high EFS expression is important to suppress a malignant behavior of prostate cancer cells. Therefore, we suggest that EFS should be considered as a novel tumor suppressor gene in prostate cancer.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK-113S433-113S290); Harran University Scientific Research Project Unit (HUBAK-13044)en_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.isversionof10.1007/s13277-014-2703-5en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectProstate canceren_US
dc.subjectDNA methylationen_US
dc.subjectEmbryonal Fyn-associated substrateen_US
dc.subjectTumoren_US
dc.titleDecreased expression of EFS is correlated with the advanced prostate canceren_US
dc.typearticleen_US
dc.contributor.iztechauthorHamid, Syed Muhammad
dc.relation.journalTumor Biologyen_US
dc.contributor.departmentİYTE, Fen Fakültesi, Moleküler Biyoloji ve Genetik Bölümüen_US
dc.identifier.volume36en_US
dc.identifier.issue2en_US
dc.identifier.startpage799en_US
dc.identifier.endpage805en_US
dc.identifier.wosWOS:000350478200039
dc.identifier.scopusSCOPUS:2-s2.0-84925497835
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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