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Title: The prognostic value of tumor-stroma proportion in laryngeal squamous cell carcinoma
Other Titles: Laringeal skuamöz hücreli karsinomlarda tümör-stroma oranının prognostik değeri
Authors: Ünlü, Mehtat
Çetinayak, Hasan Oğuz
Önder, Devrim
Ecevit, Cenk
Akman, Fadime
İkiz, Ahmet ömer
Ada, Emel
Karaçalı, Bilge
Sarıoğlu, Sülen
Keywords: Tumor
Laryngeal neoplasms
Stromal cell
Issue Date: 2013
Publisher: Federation of Turkish Pathology Societies
Source: Ünlü, M., Çetinayak, H. O., Önder, D., Ecevit, C., Akman, F., İkiz, A. Ö., Ada, E., Karaçalı, B., and Sarıoğlu, S. (2013). The prognostic value of tumor-stroma proportion in laryngeal squamous cell carcinoma. Turkish Journal of Pathology, 29(1). 27-35. doi:10.5146/tjpath.2013.01144
Abstract: Objective: Tumor-stroma proportion of tumor has been presented as a prognostic factor in some types of adenocarcinomas, but there is no information about squamous cell carcinomas and laryngeal carcinomas. Material and Method: Five digital images of the tumor sections were obtained from 85 laryngeal carcinomas. Proportion of epithelial tumor component and stroma were measured by a software tool, allowing the pathologists to mark 205.6 μm2 blocks on areas as carcinomatous/stromal, by clicking at the image. Totally, 3.451 mm2 tumor areas have been marked to 16.785 small square blocks for each case. Results: Median follow up was 48 months (range 3-194). The mean tumor-stroma proportion was 48.63+18.18. There was no difference for tumor-stroma proportion when tumor location, grade, stage and perinodal invasion were considered. Although the following results were statistically insignificant, the mean tumor-stroma proportion was the lowest (37.46±12.49) for subglottic carcinomas, and it was 52.41±37.47, 50.86+19.84 and 44.56±16.91 for supraglottic, transglottic and glottic cases. The tumor-stroma proportion was lowest in cases with perinodal invasion and the highest in cases without lymph node metastasis (44.72±20.23, 47.77±17.37, 50.05±17.34). Tumor-stroma proportion was higher in the basaloid subtype compared with the classical squamous cell carcinoma (53.76±14.70 and 48.63±18.38 respectively). The overall and disease-free survival analysis did not reveal significance for tumor-stroma proportion (p=0.08, p=0.38). Only pathological stage was an independent factor for overall survival (p=0.008). Conclusion: This is the first series investigating tumor-stroma proportion as a prognostic marker in laryngeal carcinomas proposing a new method, but the findings do not support tumor-stroma proportion as a prognostic marker.
ISSN: 1018-5615
Appears in Collections:Electrical - Electronic Engineering / Elektrik - Elektronik Mühendisliği
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
TR Dizin İndeksli Yayınlar / TR Dizin Indexed Publications Collection

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