Now showing items 1-4 of 4
Assessment of cholesterol-derived ionic copolymers as potential vectors for gene delivery
(American Chemical Society, 2013-11)
A library of cholesterol-derived ionic copolymers were previously synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization as 'smart' gene delivery vehicles that hold diverse surface charges. ...
Dicer-labile PEG conjugates for siRNA delivery
(American Chemical Society, 2011-12-12)
Poly(ethylene glycol) (PEG) conjugates of Dicer-substrate small interfering RNA (DsiRNA) have been prepared to investigate a new siRNA release strategy. 3'-sense or 5'-antisense thiol-modified, blunt-ended DsiRNAs, inhibiting ...
The endocytic pathway and therapeutic efficiency of doxorubicin conjugated cholesterol-derived polymers
(Royal Society of Chemistry, 2015-02)
Previously synthesized poly(methacrylic acid-co-cholesteryl methacrylate) P(MAA-co-CMA) copolymers were examined as potential drug delivery vehicles. P(MAA-co-CMA) copolymers were fluorescently labelled and imaged in SHEP ...
Synthesis, self-assembly and stimuli responsive properties of cholesterol conjugated polymers
(Royal Society of Chemistry, 2012-08)
Reversible addition-fragmentation chain transfer (RAFT) polymerization was used to generate well-defined pH-responsive biofunctional polymers as potential 'smart' gene delivery systems. A series of five poly(dimethylamino ...