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Quantitative trait loci that modulate trabecular bone's risk of failure during unloading and reloading
Genetic makeup of an individual is a strong determinant of the morphologic and mechanical properties of bone. Here, in an effort to identify quantitative trait loci (QTLs) for changes in the simulated mechanical parameters ...
Trabecular bone recovers from mechanical unloading primarily by restoring its mechanical function rather than its morphology
Upon returning to normal ambulatory activities, the recovery of trabecular bone lost during unloading is limited. Here, using a mouse population that displayed a large range of skeletal susceptibility to unloading and ...
Viewpoints: Feeding mechanics, diet, and dietary adaptations in early hominins
Inference of feeding adaptation in extinct species is challenging, and reconstructions of the paleobiology of our ancestors have utilized an array of analytical approaches. Comparative anatomy and finite element analysis ...
Genetic and tissue level muscle-bone interactions during unloading and reambulation
(International Society of Musculoskeletal and Neuronal Interactions, 2016-09)
Little is known about interactions between muscle and bone during the removal and application of mechanical signals. Here, we applied 3wk of hindlimb unloading followed by 3wk of reambulation to a genetically heterogeneous ...
Genetic loci that control the loss and regain of trabecular bone during unloading and reambulation
Changes in trabecular morphology during unloading and reloading are marked by large variations between individuals, implying that there is a strong genetic influence on the magnitude of the response. Here, we subjected ...