Show simple item record

dc.contributor.authorAllmer, Jens
dc.date.accessioned2017-03-06T08:30:52Z
dc.date.available2017-03-06T08:30:52Z
dc.date.issued2011-10
dc.identifier.citationAllmer, J. (2011). Algorithms for the de novo sequencing of peptides from tandem mass spectra. Expert Review of Proteomics, 8(5), 645-657. doi:10.1586/epr.11.54en_US
dc.identifier.issn1478-9450
dc.identifier.urihttp://doi.org/10.1586/epr.11.54
dc.identifier.urihttp://hdl.handle.net/11147/4976
dc.description.abstractProteomics is the study of proteins, their time- and location-dependent expression profiles, as well as their modifications and interactions. Mass spectrometry is useful to investigate many of the questions asked in proteomics. Database search methods are typically employed to identify proteins from complex mixtures. However, databases are not often available or, despite their availability, some sequences are not readily found therein. To overcome this problem, de novo sequencing can be used to directly assign a peptide sequence to a tandem mass spectrometry spectrum. Many algorithms have been proposed for de novo sequencing and a selection of them are detailed in this article. Although a standard accuracy measure has not been agreed upon in the field, relative algorithm performance is discussed. The current state of the de novo sequencing is assessed thereafter and, finally, examples are used to construct possible future perspectives of the field. © 2011 Expert Reviews Ltd.en_US
dc.description.sponsorshipThe Turkish Academy of Science (TÜBA)en_US
dc.language.isoengen_US
dc.publisherTaylor & Francisen_US
dc.relation.isversionof10.1586/epr.11.54en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTandem MSen_US
dc.subjectMass spectrometryen_US
dc.subjectDe novoen_US
dc.subjectProteomicsen_US
dc.subjectSequencingen_US
dc.titleAlgorithms for the de novo sequencing of peptides from tandem mass spectraen_US
dc.title.alternativeDe novo sequencing of MS/MS spectra
dc.typereviewen_US
dc.typesubmittedVersion
dc.contributor.authorIDTR107974en_US
dc.contributor.iztechauthorAllmer, Jens
dc.relation.journalExpert Review of Proteomicsen_US
dc.contributor.departmentİYTE, Fen Fakültesi, Moleküler Biyoloji ve Genetik Bölümüen_US
dc.identifier.volume8en_US
dc.identifier.issue5en_US
dc.identifier.startpage645en_US
dc.identifier.endpage657en_US
dc.identifier.wosWOS:000296249500014
dc.identifier.scopusSCOPUS:2-s2.0-80054760698
dc.relation.publicationcategoryDiğeren_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record