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https://hdl.handle.net/11147/4796| Title: | Multidrug Resistance Mediated by Mrp1 Gene Overexpression in Breast Cancer Patients | Authors: | Abaan, Ogan Demir Mutlu, Pelin Kaya Baran, Yusuf Atalay, Can Gündüz, Ufuk |
Keywords: | Breast cancer Chemotherapy MDR MRP Family MRP1 |
Publisher: | Taylor and Francis Ltd. | Source: | Abaan, O. D., Mutlu, P. K., Baran, Y., Atalay, C. and Gündüz, U. (2009). Multidrug resistance mediated by MRP1 gene overexpression in breast cancer patients. Cancer Investigation, 27(2), 201-205. doi:10.1080/07357900802173562 | Abstract: | Multidrug resistance (MDR) is a serious handicap towards the effective treatment of breast cancer patients. One of the most prevalent MDR mechanisms is through the overexpression of genes coding the proteins called Multidrug Resistance-associated Proteins (MRPs). The aim of this study was to investigate the expression of MRP1 in tumor tissues from breast cancer patients. In this study, a semi-quantitative RT-PCR approach was utilized. Our results suggest that MRP1 overexpression can mediate MDR in patients. Pre-evaluation of the level of such MDR mediators before chemotherapy can increase the efficacy of the treatment. | URI: | http://dx.doi.org/10.1080/07357900802173562 http://hdl.handle.net/11147/4796 |
ISSN: | 0735-7907 0735-7907 |
| Appears in Collections: | Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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