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dc.contributor.authorKosova, Buket
dc.contributor.authorTezcanlı, Burçin
dc.contributor.authorEkiz, Hüseyin Atakan
dc.contributor.authorÇakır, Zeynep
dc.contributor.authorSelvi, Nur
dc.contributor.authorDalmızrak, Ayşegül
dc.contributor.authorKartal, Melis
dc.contributor.authorGündüz, Ufuk
dc.contributor.authorBaran, Yusuf
dc.date.accessioned2016-12-15T12:35:27Z
dc.date.available2016-12-15T12:35:27Z
dc.date.issued2010-10
dc.identifier.citationKosova, B., Tezcanlı, B., Ekiz, H. A., Çakır, Z., Selvi, N., Dalmızrak, A., Kartal, M., Gündüz, U., and Baran, Y. (2010). Suppression of STAT5A increases chemotherapeutic sensitivity in imatinib-resistant and imatinib-sensitive K562 cells. Leukemia and Lymphoma, 51(10), 1895-1901. doi:10.3109/10428194.2010.507830en_US
dc.identifier.issn1042-8194
dc.identifier.urihttp://doi.org/10.3109/10428194.2010.507830
dc.identifier.urihttp://hdl.handle.net/11147/2633
dc.description.abstractSTAT proteins are cytoplasmic transcription factors that are involved in the regulation of numerous cellular activities such as cell growth, differentiation, and survival. In this study, we aimed to identify the expression pattern of STAT genes in imatinib-sensitive and-resistant K562 cells, and further, to reveal the effects of STAT5A siRNA knockdown on cell growth and apoptosis induction. The XTT cell proliferation assay showed that both sensitive and resistant K562 cells were sensitized to imatinib upon transfection with STAT5A siRNA. Caspase-3 enzyme activity was increased significantly in both cells. These results may open up new opportunities to overcome chemotherapeutic resistance in leukemia. © 2010 Informa UK, Ltd.en_US
dc.description.sponsorshipTÜBİTAK 105S459 and THD 200-02/08en_US
dc.language.isoengen_US
dc.publisherInforma Healthcareen_US
dc.relation.isversionof10.3109/10428194.2010.507830en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectsiRNA knockdownen_US
dc.subjectReversal of resistanceen_US
dc.subjectChronic myeloid leukemiaen_US
dc.subjectSmall interfering RNAen_US
dc.subjectSTAT5Aen_US
dc.subjectGene expressionen_US
dc.titleSuppression of STAT5A increases chemotherapeutic sensitivity in imatinib-resistant and imatinib-sensitive K562 cellsen_US
dc.typearticleen_US
dc.contributor.authorIDTR119533en_US
dc.contributor.authorIDTR119193en_US
dc.contributor.iztechauthorEkiz, Hüseyin Atakan
dc.contributor.iztechauthorÇakır, Zeynep
dc.contributor.iztechauthorKartal, Melis
dc.contributor.iztechauthorBaran, Yusuf
dc.relation.journalLeukemia and Lymphomaen_US
dc.contributor.departmentİYTE, Fen Fakültesi, Moleküler Biyoloji ve Genetik Bölümüen_US
dc.identifier.volume51en_US
dc.identifier.issue10en_US
dc.identifier.startpage1895en_US
dc.identifier.endpage1901en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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