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dc.contributor.authorMalay, Özge
dc.contributor.authorBatıgün, Ayşegül
dc.contributor.authorBayraktar, Oğuz
dc.date.accessioned2016-11-16T14:29:46Z
dc.date.available2016-11-16T14:29:46Z
dc.date.issued2009-10
dc.identifier.citationMalay, Ö., Batıgün, A., and Bayraktar, O. (2009). pH- and electro-responsive characteristics of silk fibroin-hyaluronic acid polyelectrolyte complex membranes. International Journal of Pharmaceutics, 380(1-2), 120-126. doi:10.1016/j.ijpharm.2009.07.011en_US
dc.identifier.issn0378-5173
dc.identifier.urihttp://dx.doi.org/10.1016/j.ijpharm.2009.07.011
dc.identifier.urihttp://hdl.handle.net/11147/2459
dc.description.abstractpH-responsiveness of recently developed silk fibroin (SF) and hyaluronic acid (HA) polyelectrolyte complex (PEC) membranes and their potential use in electro-responsive drug release systems were investigated. PEC membranes were prepared within a narrow pH window (3.0-3.5) for a SF-HA weight ratio of 20 and they were characterized by Atomic Force Microscopy in addition to characterization studies previously reported by our group. Swelling kinetics of the membranes was studied for a pH window of 2.5-7.4 and cyclic swelling test was performed to determine the pH-responsiveness of the membranes. It was shown that membranes swelled more in alkaline conditions and responded to variations in pH of the medium. Electric-stimuli assisted drug permeation and release studies were performed with a custom-made diffusion cell under both passive condition and electric field applied in pulsatile fashion. The instantaneous flux raised as the current was applied and then declined when the current application was terminated, and this process was repeated on subsequent applications. SF-HA complex membranes were found promising for the electric-stimuli-sensitive release of a high molecular weight and charged model drug for a membrane-permeation controlled formulation.en_US
dc.description.sponsorshipIzmir Institute of Technologyen_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1016/j.ijpharm.2009.07.011en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectElectro-responsiveen_US
dc.subjectFibroinen_US
dc.subjectHyaluronic aciden_US
dc.subjectPolyelectrolyte complexen_US
dc.subjectpH-responsiveen_US
dc.titlepH- and electro-responsive characteristics of silk fibroin-hyaluronic acid polyelectrolyte complex membranesen_US
dc.typearticleen_US
dc.contributor.authorIDTR131394en_US
dc.contributor.institutionauthorMalay, Özge
dc.contributor.institutionauthorBatıgün, Ayşegül
dc.contributor.institutionauthorBayraktar, Oğuz
dc.relation.journalInternational Journal of Pharmaceuticsen_US
dc.contributor.departmentIzmir Institute of Technology. Chemical Engineeringen_US
dc.identifier.volume380en_US
dc.identifier.issue1-2en_US
dc.identifier.startpage120en_US
dc.identifier.endpage126en_US
dc.identifier.wosWOS:000270495400016
dc.identifier.scopusSCOPUS:2-s2.0-69649103728
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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