Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/12736
Title: Biomimetic peptide-conjugated membranes for developing an artificial cornea
Authors: Sunal, Gülşah
Pulat, Günnur
Akgün, İsmail Hakkı
Güven, Sinan
Yıldız, Ümit Hakan
Karaman, Ozan
Horzum, Nesrin
Keywords: Corneal endothelium
Peptide synthesis
Tissue engineering
Publisher: IEEE
Abstract: The corneal endothelium is composed of a single layer of specialized endothelial cells, protecting, and nourishing the inner surface of the cornea. Corneal endothelial cells do not proliferate after birth and their number decrease with age. Trauma, inflammation, or surgical intervention can cause cell loss. When damage is extensive and the density of corneal endothelial cells decreases to a critical level, it results in corneal edema and vision loss. Besides them, when corneal endothelium has irreversible damage, the only treatment way is corneal transplantation. But there are some drawbacks such as finding donors, immune reactions, and the number of patients waiting on the transplantation lists for years. Tissue engineering approaches can provide promising alternatives for the regeneration of corneal endothelium tissue. Peptides can be used to modify and functionalize the scaffolds, allowing for the production of bioactive and biomimetic surfaces. Peptide-modified scaffold surfaces might direct and enhance the behaviors of cells. In this study, the aim was to functionalize the polycaprolactone (PCL) membranes with tissue-specific peptides and to characterize the peptide-conjugated membranes by Fourier-Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), and X-ray Photoelectron Spectroscopy (XPS) analysis. The synthesized peptides were successfully conjugated on the PCL biomembranes.
Description: The authors thank to the Scientific and Technological Research Council of Turkey (TUBITAK) (1003 Project numbers: 218S991, 219S989, and 318S275).
URI: https://doi.org/10.1109/TIPTEKNO56568.2022.9960151
https://hdl.handle.net/11147/12736
Appears in Collections:Chemistry / Kimya
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Files in This Item:
File Description SizeFormat 
Biomimetic_peptide.pdfConference Paper File439.49 kBAdobe PDFView/Open
Show full item record



CORE Recommender

SCOPUSTM   
Citations

1
checked on Mar 8, 2024

WEB OF SCIENCETM
Citations

1
checked on Mar 16, 2024

Page view(s)

72
checked on Mar 18, 2024

Download(s)

34
checked on Mar 18, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.